Biocatalyzed Synthesis in Microreactors

Besides using microreactor devices for efficient screening of biocatalysts, these can also be applied for enzymatic synthesis. Biocatalyzed reactions have recently received much attention because of the efficiency and selectivity that enzymes have to offer, combined with their ability to act under mild conditions [422,423]. Microreactors offer in this respect the advantage that enzymes can be more optimally used as a result ofthe higher mass-transfer properties of microchannels and the high surface- 

Enantioselective epoxidation Epoxide hydrolase Solution phase [424] 

Enantioselective reduction of lactic acid Lactate dehydrogenase Surface modification [425-427] 

Enantioselective reduction Alcohol dehydrogenase Solution phase [428] 

Tandem hydrolysis and oxidative coupling Lipase and peroxidase Immobilized [435] 

---