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Micromonospora carbonacea var

Polyket macrolides 27-29 membered (African termite Pseudacanthotermes spiniger Plasman 1999) naphthoQuinones granaticin Streptomyces olivaceus, Actinom., Bad. from soil in W Africa Ml) orthosomicins eveminomicin (Micromonospora carbonacea var. qfricana, Bact. frtan Kenya Nicolaou 1999)... [Pg.24]

Micromonospora carbonacea var. qfncana, Bact. from banks of Nyio River, Kenya/antibactwial... [Pg.229]

The small number of novel chlorophenol-oligosaccharide antibiotics (orthosomycins) presented in the earlier survey (7 ) has been expanded to include a few new examples. However, the highlight in this area is the total synthesis of eveminomicin 13,384-1 (ziracin Sch 27899) (2224) (2020-2022), which is found in cultures of Micromonospora carbonacea var. africana (2023-2025). This organism has also furnished the related eveminomicins 2225, 2226,13,384-5 (Sch 27900) (2227), Sch 49088 (2228) (2023-2026), and Sch 58761 (2229) (2027). [Pg.333]

Everninomycin (57) is a member of a family of oligosaccharides produced by a strain of Micromonospora carbonacea var. africana that were used as the starting point for the development of SCH-27899 as an antibiotic/Unfortunately, this compound was abandoned after Phase III studies due to its poor effi-cacy/safety profile/Everninomycins showed an excellent activity against Gram-positive bacteria, including S. pneumoniae, MRSA, VRE, and E. faecalisP They inhibit protein synthesis by interacting with the 30S subunit of ribosome and ribosomal protein L16/ " °... [Pg.128]

See other pages where Micromonospora carbonacea var is mentioned: [Pg.2554]    [Pg.314]    [Pg.441]    [Pg.441]    [Pg.441]    [Pg.2554]    [Pg.314]    [Pg.441]    [Pg.441]    [Pg.441]   


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Micromonospora carbonacea

Micromonospora carbonacea var africana

Micromonospora carbonaceae

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