Micromonospora carbonacea

Polyket macrolides 27-29 membered (African termite Pseudacanthotermes spiniger Plasman 1999) naphthoQuinones granaticin Streptomyces olivaceus, Actinom., Bad. from soil in W Africa Ml) orthosomicins eveminomicin (Micromonospora carbonacea var. qfricana, Bact. frtan Kenya Nicolaou 1999)... [Pg.24]

Micromonospora carbonacea var. qfncana, Bact. from banks of Nyio River, Kenya/antibactwial... [Pg.229]

The small number of novel chlorophenol-oligosaccharide antibiotics (orthosomycins) presented in the earlier survey (7 ) has been expanded to include a few new examples. However, the highlight in this area is the total synthesis of eveminomicin 13,384-1 (ziracin Sch 27899) (2224) (2020-2022), which is found in cultures of Micromonospora carbonacea var. africana (2023-2025). This organism has also furnished the related eveminomicins 2225, 2226,13,384-5 (Sch 27900) (2227), Sch 49088 (2228) (2023-2026), and Sch 58761 (2229) (2027). [Pg.333]

Everninomycin (57) is a member of a family of oligosaccharides produced by a strain of Micromonospora carbonacea var. africana that were used as the starting point for the development of SCH-27899 as an antibiotic/Unfortunately, this compound was abandoned after Phase III studies due to its poor effi-cacy/safety profile/Everninomycins showed an excellent activity against Gram-positive bacteria, including S. pneumoniae, MRSA, VRE, and E. faecalisP They inhibit protein synthesis by interacting with the 30S subunit of ribosome and ribosomal protein L16/ " °... [Pg.128]

After extensive NMR and mass spectrometric study the structure of the complex and novel octosaccharide 45 isolated from the fermentation broth of Micromonospora carbonaceae has been reported. ... [Pg.78]

Oligosaccharide antibiotic. Prod, by Micromonospora carbonaceae. Highly active against gram-positive bacteria, clinically used against infections caused by resistant bacteria. Amorph. Sol. EtOAc, Me2CO poorly sol. hexane. [ ]d -47.2 (MeOH). Related to Ever-ninomicin B, E-33. 215 268 301... [Pg.441]

Chloro Antibiotic Sch 58761. Sch 58761 C70H96CI3NO38 1665.87 Prod, by Micromonospora carbonaceae. Active against multidrug-resistant bacteria. Amorph. powder. Mpl83-185°.[a]g-48.4(c,0.1 in MeOH). 3 -Dechloro Antibiotic Sch 58771. Sch 58771... [Pg.441]

Oligosaccharide antibiotic. Isol. from Micromonospora carbonaceae. Active against gram-positive bacteria and mycobacteria. Sol. MeOH, bases, CHCI3 fairly sol. C Hs poorly sol. Et20, H2O, hexane. [Pg.442]

C66H99CI2NO35 1537.399 Prod, by Micromonospora carbonaceae. Amorph. solid. Sol. MeOH, bases, CHCI3 fairly sol. Et20 poorly sol. C5H5, hexane, H2O. [a]o -34.2. Xmax 300 (e 6360) (MeOH) (Derep). Vax 289 (El%/lcm 22) (MeOH) (Berdy). Vax 295 (El%/lcm 80.8) (MeOH-NaOH) (Berdy). [Pg.442]

The structure (336) of the octasaccharide antibiotic eveminomycin D produced by Micromonospora carbonaceae has been reported by Ganguly and his coworkers. Orthoester linkages akin to that present in eveminomycin D are also found in destomycins A, B, and C, which chemical and spectroscopic evidence indicated to have the structures (337) each antibiotic contains a 6-amino-6-deoxyheptopyranosylidene residue attached to a D-hexose residue, which is linked in turn to streptamine. o-Talose is the hexose component of destomycins A and C. [Pg.131]

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