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Micromonospora carbonacea var africana

The small number of novel chlorophenol-oligosaccharide antibiotics (orthosomycins) presented in the earlier survey (7 ) has been expanded to include a few new examples. However, the highlight in this area is the total synthesis of eveminomicin 13,384-1 (ziracin Sch 27899) (2224) (2020-2022), which is found in cultures of Micromonospora carbonacea var. africana (2023-2025). This organism has also furnished the related eveminomicins 2225, 2226,13,384-5 (Sch 27900) (2227), Sch 49088 (2228) (2023-2026), and Sch 58761 (2229) (2027). [Pg.333]

Everninomycin (57) is a member of a family of oligosaccharides produced by a strain of Micromonospora carbonacea var. africana that were used as the starting point for the development of SCH-27899 as an antibiotic/Unfortunately, this compound was abandoned after Phase III studies due to its poor effi-cacy/safety profile/Everninomycins showed an excellent activity against Gram-positive bacteria, including S. pneumoniae, MRSA, VRE, and E. faecalisP They inhibit protein synthesis by interacting with the 30S subunit of ribosome and ribosomal protein L16/ " °... [Pg.128]

See other pages where Micromonospora carbonacea var africana is mentioned: [Pg.2554]    [Pg.314]    [Pg.441]    [Pg.441]    [Pg.441]    [Pg.2554]    [Pg.314]    [Pg.441]    [Pg.441]    [Pg.441]   
See also in sourсe #XX -- [ Pg.314 ]



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Micromonospora carbonacea

Micromonospora carbonacea var

Micromonospora carbonaceae

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