Streptomyces olivaceus

Nocardia rugosa Propionibacterium arabinosum Propionibacteriumfreudenreichii Propionibacterium pentosaceum Propionibacterium peterssoni Propionibacterium shermanii Propionibacterium technicum Propionibacterium vannielli Protaminobacter ruber Pseudomonas denitrificans Bhi bium meliloti Bhodopseudomonas capsulata Bhodopseudomonas spheroides Strigomonas oncopelti Streptomyces aureofaciens Streptomyces griseus Streptomyces olivaceus... 

Josamydn Maridomycin I Narbomycin Narbonolide 3 -OH-Josamydn 3 -OH-Maridomydn I Picromydn Picronolide Streptomyces olivaceus Streptomyces narbonensis Streptomyces zaomyceticus... 

Cobalamin (vitamin B12) Streptomyces olivaceus Food supplements... 

Fig. 9.26 NFS spectra from ferritin of the bacterium Streptomyces olivaceus. (Taken from [7])...

Polyket macrolides 27-29 membered (African termite Pseudacanthotermes spiniger Plasman 1999) naphthoQuinones granaticin Streptomyces olivaceus, Actinom., Bad. from soil in W Africa Ml) orthosomicins eveminomicin (Micromonospora carbonacea var. qfricana, Bact. frtan Kenya Nicolaou 1999)... 

A new metabolite from Streptomyces olivaceus has been shown to be (2S)-1-oxo-2,3-dihydropyrrolizine-3-carboxylic acid (15b) by total synthesis. The pyrrolizine ring was formed from the pyrrole (14) by stereoselective cyclization with phosphorus pentoxide in toluene in 37% yield. Partial racemization occurred during the hydrolysis of ester 15a.21... 

Blanco G, Patallo EP, Brana AF et al (2001) Identification of a sugar flexible glycosyltrans-ferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin. Chem Biol 8 253-263... 

Glucose Isomerase isomerase (1) Actinoplanes missouriensis (2) Bacillus coagulans (3) Streptomyces olivaceus (4) Streptomyces d-xylose ketoisomerase 5.3.1.5... 

Glucose Isomerase (Actinoplanes missouriensis, Bacillus coagu-lans, Streptomyces olivaceus, Streptomyces olivochromogenes,... 

Glassy Sodium Polyphosphates, 55 a-D-Glucopyranosyl-1,4-D-glucitol, 33 Glucose Isomerase (Actinoplanes missouriensis, Bacillus coagulans, Streptomyces olivaceus, Streptomyces olivochromogenes, Microbacteruim arborescens, Streptomyces... 

Application of the above screen led to the detection of a number of /8-lactamase inhibitors from a number of strains of Streptomyces olivaceus. They were identified as the carbapenem derivatives, MM 13902 (12), MM 4550 (13) and MM 17880 (14), known collectively as the olivanic acids [27, 28]. Not only are they potent -lactamase inhibitors, but are also powerful antibacterial agents. Subsequently, a whole series of carbapenem derivatives... 

A short time after the isolation of the olivanic acids from Streptomyces olivaceus, Beecham scientists detected another potent y9-lactamase inhibitor in a culture of Streptomyces clavuligerus. This inhibitor was isolated and characterized as clavulanic acid (17) [34, 35]. Whilst this compound has only... 

Josamydn Maridomydn 1 3 -OH-Josamydn 3 "-OH-Maridomydn I Streptomyces olivaceus... 

Decker,H., J. Rohr, H. Motamedi, H. Zahner and C.R. Hutchinson (1995). Identification of Streptomyces olivaceus TU2353 genes involved in the production of the polyketide elloramycin. Gene 166 121-126. 

Simple lactams with the pyrrolizidine skeleton (pyrro-lams) are isolated from Streptomyces olivaceus. Biosynthesis physiology The necine bases are formed from arginine. The necinic acids are mostly derived from the amino acids isoleucine, leucine, and valine. The P. a are formed in the roots of Senecio species and are stored intracellularly in the vacuoles of the inflorescence, epidermal tissues, etc. The corresponding N-oxides are the transport and storage forms and are easily reduced to the tertiary amines on processing. The genuine tertiary amines are only found in the dried seeds. 

Schubert et al. (1967) have isolated cholesterol from Streptomyces olivaceus. This is a species of the order Actinomycetales. These workers used chromatography, mass spectrometric, and infrared spectroscopic methods for the isolation and identification. S. olivaceus can degrade as well as synthesize cholesterol. 

Pyrrolizidinones are likewise accessible from prolinates. (-)-(J )-Pyrrolam A (76), which was isolated by Zeeck et al. [57] from Streptomyces olivaceus... 

Glucose isomerase (Xylose isomerase) EC 5.3.1.5 Bacillus coagulans Arthrobacter spec. Streptomyces olivaceus Streptomyces phaeochromogenes Glucose High fructose com syrup (HFCS)... 

The microorganism Streptomyces olivaceus produces a number of P lactam antibiotics and P-lactamase inhibitors which have collectively become known as the olivanic acids 49, 69—75). Together with other streptomycete metabolites such as thienamycin 80, 81), PS-5 85, 86), the carpetimycins 90, 91) and the asparenomycins 92), they form a family of natural products characterised by the presence of the l-carbadethiapen-2-em (7-oxo-l-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid) ring system (94). The simplest member of the family is the completely unsubstituted nucleus (94), recently isolated from various species of Serratia and Erwinia 98). All the other natural products possess substituents at C(2) and C(6) of this nucleus, the former being attached by way of a sulphur linkage. Differences in the nature and stereochemistry of these substituents have provided a wide variety of structures. Almost forty natural variations of this ring system are now known and these are listed in Table 5. 

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