Microfluidic modelling

In order to further investigate and understand the unfavorable results regarding sample elution time of the weir-SMEC as compared to the grid-SMEC, microfluidic modeling of the flow profile immediately after the weir was performed. When the size of fluidic channels is in the dimensions of a few hundred micrometers or smaller and aqueous-based solutions are used, it is well known that pressure-driven fluid transport is usually heavily dominated by laminar flow. Therefore microfluidic modeling can be employed to investigate and study fluid flow characteristics in microchip designs prior to fabrication. 

Namdee, K., Thompson, A.J., Charoenphol, P., Eniola-Adefeso, O. Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels. Langmuir 29, 2530-2535 (2013). doi 10.1021/la304746p... 

Zhang J (2011) Lattice Boltzmann method for microfluidics models and applications. Microfluid Nanofluid 10 1-28... 

Alfadhel, K.A. and Kothare, M.V. (2005) Microfluidic modeling and simulation of flow in membrane microreactors. Chem. 

Since the effective reaction order for this example is greater than 1, we should have known a priori that the macrofluid model would predict a higher conversion than the microfluid model. Moreover, based on our discussion of CSTRs in series in Chapter 4, we should have known that N = 3 would give a higher conversion that N = 2. Therefore, we could have bracketed the above results with two calculations N = 2/microfluid (lowest conversion) and N = 3/macrofluid (highest conversion). 

Siyon Chung obtained her BSc in Chemistry from the University of Western Ontario, Canada in 2009. She mov to the University of Toronto to puisue her MSc with Prof Eugenia Kumacheva in the field of polymer and material chemistry. Her current research focuses on the self-assembly of inoi anic NRs, microfluidic generation of polymer microgels, and microfluidic modeling of cell flow in microvasculature. 

The development of start-up companies in the field of micro-systems technology, including microfluidics, has been reviewed by Wicht et al. [244]. Different types of business models are presented as well as the corresponding growth models. The development of start-ups in Germany in the last 10 years is presented and the product offer is discussed. This is compared with the situation in other European countries. Finally, information on problems and opportimities for the start-ups is provided. 

Fig. 2.6.11 Flow dispersion profiles obtained with (a) a capillary, (b) with a model microfluidic chip device containing a channel enlargement, directly connected to a capillary and (c) with the same microfluidic chip connected to a capillary via a small mixing volume. A sketch of the model microfluidic device is placed at the right side of each image, drawn to...

Cell potential, 9 607-609 standard, 75 750 Cell Saver, 3 719 Cells, encapsulation of, 76 454 Cell sorting, microfluidics in, 26 971-972 Cell-specific dendritic carriers, 26 797 Cell targeting, dendrimers in, 26 797-798 Cell thermo stating, 73 426 Cellular components inducers, herbicide damage to, 73 297-298 Cellular damage, in aging, 2 810 Cellular diseases, yeast as a model for, 26 496-497... 

Inner slip, between the solid wall and an adsorbed film, will also influence the surface-liquid boundary conditions and have important effects on stress propagation from the liquid to the solid substrate. Linked to this concept, especially on a biomolecular level, is the concept of stochastic coupling. At the molecular level, small fluctuations about the ensemble average could affect the interfacial dynamics and lead to large shifts in the detectable boundary condition. One of our main interests in this area is to study the relaxation time of interfacial bonds using slip models. Stochastic boundary conditions could also prove to be all but necessary in modeling the behavior and interactions of biomolecules at surfaces, especially with the proliferation of microfluidic chemical devices and the importance of studying small scales. 

Despite the fact that much effort has been made to model the DMFC system, considerable work remains, particularly in support of the emerging portable designs and systems. Few have treated the dominating effects of two-phase flow. No model to date has sufficient detail to provide a microfluidic theory for portable systems including effects of channel geometry and wettability characteristics of the GDL on fluid flow in the anode or cathode. Modeling studies are needed to fully elucidate the intricate couplings of methanol, water, and heat-transport... 

For microfluids in plug or mixed flow we have developed the equations in the earlier chapters. For intermediate flow we will develop appropriate models in Chapters 12, 13, and 14. 

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