Microfluidic microreaction technology

The following discussions present recent developments that may contribute to the development of new proteomic tools through microfluidic microreaction technology. 

D., Hocker, H., Legewie, F., Poprawe, R., Wehner, M., Wild, M., Laser processing for manufacturing microfluidic devices, in Eheeeld, W. (Ed.), Microreaction Technology 3rd International Conference on Microreaction Technology, Proc. of IMRET 3, pp. 80-89, Springer-Verlag, Berlin (2000). 

J. Przekwas, A. Przekwas, Simulation of Biochemical Reaction Kinetics in Microfluidic Systems, IMRET3 Proceedings of the Third International Conference on Microreaction Technology, Springer, Berlin Heidelberg, New York, 2000, p. 441-450. 

M., Microfluidic on ASIC - a novel concept for an integrated lab on a chip, in Proceedings of the 6th International Conference on Microreaction Technology, IMRET 6 (11-14 March 2002), AIChE Pub. No. 164, New Orleans, 2002, 326-328. 

Giovannini, H., New process for manufacturing ceramic microfluidic devices for microreactor and bioanalytical applications, in Matlosz, M., Ehrfeld, W., Baselt, J. P. (Eds.), Microreaction Technology - IMRET 5 Proc. of the 5th International Conference on Microreaction Technology, Springer-Verlag, Berlin, 2001, 103-112. 

The electron density in the nano wire was adjusted electrically, and in this way oxidation and reduction reactions at the surface of the Sn02 wire could be modified by tuning the density of oxygen vacancies in the surface layer. This work is a very nice demonstration of the merger of different fields, that is, catalysis, nanotechnology, and microelectronics, and it would be quite feasible to combine this with microfluidics. It is quite possible that this is the direction in which the field of microreaction technology in future will develop. 

Bibby, I.P., Harper, M.J. and Shaw, J. (1998) Design and optimisation of microfluidic reactors through CFD and analytical modelling, in Process Miniaturization 2nd International Conference on Microreaction Technology, IMRET2 Topical Conference Preprints (eds W. Ehrfeld, I.H. Rinard and R.S. Wegeng), AIChE, New Orleans, USA, pp. 335-339. 

Microfluidic systems (microreactors) provide great benefits, such as precise fluid-manipulation [1] and high controllability of rapid and difficult to control chemical reactions (see Part 2, Bulk and Fine Chemistry). Advantages of microreaction technology have been utilized in polymer chemistry notable examples include the synthesis of fine solid polymeric materials [2,3] and excellent control of exceptionally reactive polymerization through mainly radical and cationic polymerization reactions (see Chapters 13-15). Other polymerizations using microreaction technology are still in their infancy, vhich include step polymerization, that is, polycondensation and polyaddition and other non-radical polymerizations. 

M. Bouquey, S. Serra, L. Prat, G. Hadziioannou, Microfluidic synthesis and assembly of reactive polymer beads to form new structured polymer materials, in Book of Abstracts of the 9th International Conference on Microreaction Technology, IMRET 9, 6-8 September 2006, Potsdam/ Berlin, 2006, pp. 104—105. 

Reactions require accurate dosage of reactants to achieve the optimum stoichiometry. An array of components for fluid manipulation have been developed over the last decade for micrototal analysis systems ( xTAS) and microreaction technology. Pumping of fluids is carried out using microfluidic components, which can be classified as either mechanical or nonmechanical. Mechanical pumps are distinguished from nonmechanical pumps by the presence of a moving physical part. 

The examples given in this chapter demonstrate that the ozonolysis can be performed in microfluidic reactors in a safe and controllable manner. A lot of knowledge was gained on the processing of the ozonolysis in microfluidic devices on laboratory as well as on pilot plant scale. Nobis and Roberge summarized the advantages of microreaction technology for ozonolysis reactions from an industrial point of view [39]. 

Many researchers have studied the interfacial science and technology of laminar flow in microfluidics [8]. Interfacial polymerization and the subsequent formation of solid micro structures, such as membranes and fibers in a laminar flow system, are very interesting techniques because the bottom-up method through polymerization is suitable for the formation of miniature structures in a microspace [3]. The development of such microstructure systems plays an important role for the integration of various microfluidic operations and microchemical processing [9]. For instance, membrane formation in a microchannel and further modification has a strong potential for useful functions such as microseparation, microreaction and biochemical analysis [8-10]. Here, we will introduce several reports on polyamide and protein membrane formation through interfadal polycondensation in a microflow. 

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