Micrototal analysis system

Linder D., The pChemLab project micrototal analysis system R D at Sandia National Laboratories, Lab on a Chip. 2001 1 15N-19N. 

King, K.R. Terai, H. Wang, C.C. Vacanti, J.P. Borenstein, J.T. Microfluidics for tissue engineering microvasculatuer endothelial cell culture. In Micrototal Analysis Systems 2001 Proceedings of the 5th Ptas 2001 Symposium, Monterey, CA, USA, October 21-25, 2001 247-249. 

Chemical analysis Micrototal analysis system Lab-on-a-chip Synthesis for screening Combinatorial synthesis ... 

The rapid progress in this field meant that the 1st International Conference on Micrototal Analysis System was held at Twente University, The Netherlands, in 1994. Since then, tremendous developments have been achieved in this field throughout the world. 

Ito, T., Sobue, K., and Ohya, S., Water glass bonding for micrototal analysis system. Sens. Actuat. B,... 

The development of microfabricated devices for analytical applications has been pioneered by Manz, Harrison, Widmer, Jacobson, and Ramsey in the early 1990s. Since then, significant efforts have been invested to advance the theoretical foundations and the application areas of microfluidics. Under the generic name of Lab-on-a-Chip (LOC) or Micrototal Analysis Systems (fiTAS),... 

Greenwood, P.A., Greenway, GM., Sample manipulation in micrototal analysis systems. Trends Anal. Chem., 21, 726-740, 2002. 

Biochemical analysis on nanoliter scale is precisely carried out by micrototal analysis system (pTAS) which consists of microreactors, microfluidic systems, and detectors. Performance of the pTAS depends on micromachined and electrochemically actuated micropump capable of precise dosing of nanoliter amounts of liquids such as reagents, indicators, or calibration fluids [28]. The dosing system is based on the displacement of the liquid from a reservoir which is actuated by gas bubbles produced electrochemically. Electrochemical pump and dosing system consist of a channel structure micro-machined in silicon closed by Pyrex covered with novel metal electrodes. By applying pulsed current to the electrodes, gas bubbles are produced by electrolysis of water. The liquid stored in the meander is driven out into the microchannel structure due to expansion of gas bubbles in the reservoir as shown in Fig. 11.8. 

Lab-on-a-Chip Micrototal analysis system (pTAS) Miniaturized analysis systems... 

The first instance of DNA separation by microchip electrophoresis was in 1994. A mixture of DNA oligomers from 10 to 15 bases was efficiently separated. Since then, microchip electrophoresis for DNA separation has developed very quickly. DNA sequencing of 200 bases by microchip takes only 10 min in cross-linked polyacrylamide gels. ° By using 4% LPA in 7 cm-long coated microchannels, 600 bases were separated in 20 min at 160 V/cm. Four-color LIF detection is feasible in micrototal analysis system (p.TAS) use. 

A. van der Berg, P. Bergveld (Eds.), Micrototal Analysis Systems, Kluwer Academic Press, Boston, 1995. 

Xu, X.L., Zhang, S., Chen, H. and Kong, J.L. (2009) Integration of electrochemistry in micrototal analysis systems for biochemical assays recent developments. Talanta, 80, 8-18. 

In the past two decades, the biological and medical fields have seen great advances in the development of biochips capable of characterizing and quantifying biomolecules. Biochips, also known as labs on a chip or jxTAS (micrototal analysis systems), are microscale systems that interact with biological components on their characteristic length scale. Many biochips work with particles (cells, bacteria, DNA, etc.) suspended in fluids. 

Reactions require accurate dosage of reactants to achieve the optimum stoichiometry. An array of components for fluid manipulation have been developed over the last decade for micrototal analysis systems ( xTAS) and microreaction technology. Pumping of fluids is carried out using microfluidic components, which can be classified as either mechanical or nonmechanical. Mechanical pumps are distinguished from nonmechanical pumps by the presence of a moving physical part. 

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