Microfluidic devices circulating tumor cells

Cell enumeration/cytometiy in microfluidic devices Circulating tumor ceU detectitMi HIV diagnostics Whole blood counting... 

Potential Future Uses of Microfluidic Devices Analysis of Circulating Tumor Cells... 

The most common tumor-on-a-chip platforms are the cancer marker detecting devices. Usually, the microfluidics devices with specially design channel structures can collect circulating tumor cells [49, 77-79]. Nanoparticle screening platforms to create a microenvironment that mimics tumor tissues and nearby vessels were also used [28] in drug screening and delivery systems. A tumor-on-a-chip... 

Microvortices created within the expansion zone of a microchannel are used for label-free isolation and enrichment of rare cells within an aqueous sample, where there is sufficient size difference between rare cells and the rest of the sample. This method allows for cell separation in a high-throughput, size, and density-based manner, where target cells are concentrated from tens of milliliters of volume into smaller microliter scale volumes [9]. In this manner, isolation of cancer cells from the human blood (circulating tumor cells, CTCs) has been demonstrated using a microfluidic device generating massively parallel laminar microscale vortices. 

Kang JH, Krause S, Tobin H et al (2012) A cmnbined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip... 

Kirby BJ, Jodari M, Loftus MS et al (2012) Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device. PLoS One 7 e35976... 

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