Microcrystalline cellulose tablets

Bentonite Suspending agent Microcrystalline cellulose Tablet binder... 

Kuentz, M. T., Leuenberger, H., and Kolb, M. (1999), Fracture in disordered media and tensile strength of microcrystalline cellulose tablets at low relative densities, Int. J. Pharm., 182, 243-255. 

Kuentz, M. T., and Leuenberger, H. (1998), Modified Young s modulus of microcrystalline cellulose tablets and the directed continuum percolation model, Pharm. Dev. Technol., 3(1), 1-7. 

Fig. 20 Compression force vs. hardness plots for microcrystalline cellulose tablets with 0.07 and 5.1% MC. (The points represent individual tablets collected during manufacture.)...

Akande, O.F. Ford, J.L. Rowe, P.H. Rubinstein, M.H. The effects of lag-time and dwell-time on the compaction properties of 1 1 paracetamol/ microcrystalline cellulose tablets prepared by pre-compression and main compression. J. Pharm. Pharmacol. 1998, 50, 19-28. 

Nilsson M, Mihranyan A, Valizadeh S, et al. Mesopore structure of microcrystalline cellulose tablets characterized by nitrogen adsorption and SEM the influence on water-induced ionic conduction. J Phys Chem B 2006 110 15776-15781. 

Ek R, Hill RM, Newton JM. Low frequency dielectric spectroscopy characterization of microcrystalline cellulose, tablets and paper. J Mater Sci 1997 32 4807-4814. 

Westerhuis JA, de Haan P, Zwinkels J, Jansen WT, Coenegracht PJM, Lerk CF. Optimization of the composition and production of mannitol/microcrystalline cellulose tablets. Int J Pharm 1996 143 151-162. 

Some tablets combine sustained-release and rapid disintegration characteristics. Products such as K-Dur (Key Pharmaceuticals) combine coated potassium chloride crystals in a rapidly releasing tablet. In this particular instance, the crystals are coated with ethylcellulose, a water-insoluble polymer, and are then incorporated into a rapidly disintegrating microcrystalline cellulose (MCC) matrix. The purpose of this tablet is to minimize GI ulceration, commonly encountered by patients treated with potassium chloride. This simple but elegant formulation is an example of a solid dosage form strategy used to achieve clinical goals. 

Fig. 12 Percent weight gain associated with the exposure of tablet formulations to 80% relative humidity at 40°C. Formulation A (0) was essentially a 1 11 blend of the drug entity and microcrystalline cellulose, while formulation B ( ) was essentially 1 5.5 5.5 drug-microcrystalline cellulose-starch.

It is a yellow solid with a solubility in water of 0.007 mg/mL. The Tykerb tablet contains 405 mg of the active ingredient, and the inactives are magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate. 

Nogami, H., Nagai, T., Fukuoka, E., and Sonobe, T., Disintegration of the aspirin tablets containing potato starch and microcrystalline cellulose in various concentrations, Chem. Pharm. Bull., 17 1450-1455 (1969). 

Fig. 1—Influence of thermal treatment on the drug release from tablets containing 15% HMW DL-PLA, 25% theophylline and 60% microcrystalline cellulose.

Dissolution profiles from tablets containing 60% theophylline and 25% microcrystallme cellulose showed a smaller difference in the release rate of theophylline from heated and non-heated tablets (Fig. 3). Nevertheless, both of these tablets demonstrated a matrix-controlled release. These results suggest that the level of excipient in the tablet exerted a significant effect on the dissolution release properties of thermally and non-thermally treated tablets. As the microcrystalline cellulose content increased, the difference in release rates between heated and non-heated tablets became more pronounced. 

Staniforth JN, Chatrath M. Towards a new class of high functionality tablet binders. I Quasi-hornification of microcrystalline cellulose and loss of functionality. Pharm Res 1996 13 S208. 

For the pharmaceutical product development scientist, there is clearly a need for objective information about the practical performance of different excipients and their various grades. In this chapter we set out to bring together the results of some of our ongoing evaluations of the physical and mechanical properties of excipients commonly used for the manufacture of solid oral dosage forms. In this particular article, we have chosen to focus on the fillers that are most commonly used in the manufacture of immediate release tablets microcrystalline cellulose (MCC), lactose, calcium phosphate, and mannitol (1). 

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