Suspending agents microcrystalline cellulose

Bentonite Suspending agent Microcrystalline cellulose Tablet binder... 

Cellulose (Figure 8.19) may be extracted from wood pulp, and is usually partially hydrolysed with acid to give microcrystalline cellulose. These materials are used as tablet diluents. Semi-synthetic derivatives of cellulose, e.g. methylcellulose, hydroxymethylcellulose, and carboxymethylcellulose, are used as emulsifying and suspending agents. Cellulose acetate phthalate is cellulose with about half the hydroxyl groups acetylated, and the remainder esterified with phthalic acid. It is used as an acid-resistant enteric coating for tablets and capsules. 

Suspending agent systems such as a pseudoplastic (sodium carboxymethylcellulose) in combination with a clay (hydrated colloidal magnesium aluminum silicate) or blends and coprecipitates of sodium carboxymethylcellulose and microcrystalline cellulose exhibit some thixotropic flow characteristics. Other pseudoplastics such as hydroxyethylcellulose or hydroxy-propyl methyl cellulose may be required to overcome possible in compatibilities with sodium carboxymethylcellulose. 

Nevertheless, simpler suspending and flavouring agents can also be prepared at the dispensary (e.g. methylcellulose 1%, or other celluloses such as hypromellose, microcrystalline cellulose, sodium carboxy-methylcellulose at 1-2%, xanthan gels, pharmacopoeial syrups, or mixtures of the above). In some formulations suspending agents may not be required, for example, when it is known that the drug is soluble... 

Colloidal grades of microcrystalline cellulose, coproduced and dried with cellulose gum, function as nonmigrating binders and suspending agents in glaze slips. Performs as efficient binder/lubricants and extrusion aids in aqneons systems. 

Chem. Descrip. Microcrystalline cellulose and cellulose gum USP/NF CAS 9004-34-6 9004-32-4 EINECS/ELINCS 232-674-9 Uses Fat replacement, mouthfeel enhancer in foods stabilizer in low-fat emulsions foam stabilizer, ice crystal growth control agent, syneresis inhibitor, vise, builder, opacifier, particulate suspending agent in frozen desserts, whipped toppings excipient, vehicle, vise, control agent, thixotrope for pharmaceutical suspensions and emulsions... 

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