Microarray application

Angenendt, R, Glokler, J., Sobek, J., Lehrach, H., and Cahill, D.J., Next generation of protein microarray support materials Chromatography A 1009 97-104, 2003. evaluation for protein and antibody microarray applications. 

Slides specifically selected for microarray applications should be used. They are available as ultracleaned (an important consideration) and untreated for those who wish to prepare their own surfaces or they can be purchased with a variety of precoated surface chemistries (e.g., lysine, aldehyde, or epoxide). The densities of reactive groups and surface coating uniformity are difficult to control. Thus, if lot-to-lot slide consistency is most important factor, consider using commercially available slides that are quality controlled. 

While it would be difficult to provide a comprehensive overview of microarray applications, the following survey should provide ample proof of the continued expansion of microarray use into diverse fields. 

Stoll, D., et al. (2005) Protein microarrays applications and future challenges. Curr Opin Dru Discov Devel. 8, 239-52. 

Multiplex Minisequencing on Microarrays Application to Pharmacogenetics of Antihypertensive Drug Response... 

Figure 14.16 Set of pins built within a print head for contact printing in microarray applications. (Image courtesy of The Netherlands Cancer Institute, W. Brugman.)...

FIGURE 23.2 Stokes shift diagram depicting optimal relationships between excitation and fluorescence light of a fluorophore suitable for microarray applications. 

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