Gene expression Microarray-based applications

Chapter five Gene expression Microarray-based applications... 

In the case of immunoglobulin, microarray data indicated the opposite effect that the Fc-receptor is elevated in chronic MS but not in acute lesions. Using Fcy-receptor knockout mice, the disease was found to be absent. Inter-venous immrmoglobulin therapy in the EAE mouse model was reported (see Lock, 2002, Reference 29). In summary. Lock et al. were able to apply the results of microarray-based gene expression clustering of a human disease pathological state (acute vs. chronic MS) to successfully identify fherapeutic targets for an animal model (EAE) potentially applicable to the human condition. 

This chapter will review some of the key applications presented by protein microarrays. The use of profein microarrays sfems from works on gene expression arrays described earlier. However, rmlike ifs predecessors whose process formats (mutation detection, polymorphism screening, gene expression analysis, etc.) are essentially based upon solid-phase hybridization of nucleic acid complementary strands, the protein array may play different roles and comprise a variety of formafs. 

IV. APPLICATION OF MICROARRAY-BASED GENE EXPRESSION PROFILING ANALYSIS TO THE CHARACTERIZATION OF THE HORMONE-RESPONSIVE PHENOTYPE OF BREAST CANCER... 

Budach W, Neuschafer D, Wanke C et al (2003) Generation of transducers for fluorescence-based microarrays with enhanced sensitivity and their application for gene expression profiling. Anal Chem 75 2571-2577... 

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