Mice, lung adenomas

Busby WF Jr, Cfoldman ME, Newbeme PM, Wogan GN Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. Carcinogenesis 5 1311-1316, 1984... 

In the second mouse lung adenoma assay, cinnamyl anthranilate was administered to 15 females and 15 males under similar experimental conditions, except that redistilled tricaprylin was used as the vehicle. The control group consisted of 80 females and 80 males. The numbers of tumours per mouse were increased at the high dose, being 0.85 0.23 (p < 0.01) in high-dose females, 1.40 0.36 p < 0.001) in high-dose males, 0.54 0.15 (p < 0.05) in low-dose females and 0.47 0.12 in low-dose males compared with 0.20 0.02 in control females and 0.24 0.03 in control males (Stoner etal., 1973). 

In a mouse-lung adenoma assay, 1,4-dioxane produced a significant increase in the... 

Mirvish, S.S., A. Cardesa, L. Wallcave, and P. Shubik. 1975. Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds effect of ascorbate, gallis acid, thio cyanate, and caffeine.. Natl. Cancer Inst. 55 633-636. 

Mouse i.p. Lung (Adenoma, Adeno carcinoma) Salivary glands ( ) 29,47,48 29... 

For example, 7,12-dimethylbenz[a]anthracene is a particularly potent carcinogen for the mammary gland of young female Sprague-Dawley rats after oral or intravenous administration (25,26), dietary benzo[a]pyrene leads to leukemia, lung adenoma and stomach tumors in mice (27), and either of these hydrocarbons can induce hepatomas in male mice when injected on the first day of life (28). Nevertheless, the mouse skin system has proved to be particularly valuable because of the rapidity of tumor induction, the ease of detection of tumors and because the multi-stage nature of the carcinogenic process was experimentally established in this system. 

Compound Dose (pimol) 7o Mice with Tumors Av. Tumors per Mouse Dose (pimo 1) % Mice with Lung Adenoma Adenoma per Mouse... 

Tumor Initiation in Mouse Skin Metabolite Activity/Activity of BP at Same Dose Lung Adenoma Induction in Newborn Mice Metabolite Activity/Activity of BP at Same Dose ... 

Compound Dose (pmol) % Mice with tumors Av. tumors per mouse Dose (pmol) % Mice with lung adenoma Adenoma per mouse... 

The lARC considers that there is sufficient evidence that BA is carcinogenic to experimental animals. BA has produced carcinogenic results in the mouse by gavage, intraperitoneal, subcutaneous, or intramuscular routes of administration. It caused hepatomas and lung adenomas after gavage administration of 15 doses of 1.5 mg each over a period of 5 weeks early in the lifetime of the mice. ... 

Kauffman, S.L., Alexander, L., and Saas, L. (1979). Histological and ultrastructural features of the Clara cell adenoma of the mouse lung, Lab. Invest. 40,708. 

Benzotrichloride was tested in three studies by skin application to female mice. It produced squamous cell carcinomas of the skin and lung tumours in all three experiments upper digestive tract tumours were also observ ed in two of the three experiments. Increases in the incidence of tumours at other sites were reported. In a strain A mouse lung tumour bioassay, benzotrichloride increased the incidence of lung adenomas (lARC, 1982, 1987a). 

Mouse. In a strain A lung adenoma assay, intraperitoneal injection of total doses of 20, 50 or 100 mg/kg bw epichlorohydrin given three times per week for eight weeks significantly increased the number of lung tumours per mouse in males treated with the highest dose (0.80 0.68, compared with 0.47 0.63 in controls p < 0.01) but not in other groups (Stoner et al., 1986). 

Benz[a]anthracene has been shown to be carcinogenic to experimental animals. Benz[a]anthracene given by several routes of administration has proven to be carcinogenic in mouse. Following repeated administration to young mice, it produced hepatomas and lung adenomas. 

No information was identified on the chronic reproductive, developmental, or carcinogenic effects of carbonyl sulfide in animals. Flowever, carbonyl sulfide is the oxidation product of carbon disulfide, which has been shown by the National Institute of Flealth to be positive in the strain A mouse lung tumor bioassay. Significant increases in the incidence (tumor-bearing mouse) and frequency (tumors per mouse of lung adenomas) was observed in A/J mice. 

Chronic effects in humans following cypermethrin exposure have not been reported. Studies have demonstrated possible genotoxicity in mouse spleen and bone marrow. US Environment Protection Agency has classified cypermethrin as a possible human carcinogen based on findings of benign lung adenomas in mice. 

Daily diet treatment with 9.5 mg/kg for one week produced kidney and lung adenomas in mice (Terracini et al. 1966). No other acute duration oral carcinogenicity studies were found in the reviewed literature. The CEL from the mouse study is presented in the acute duration category in Table 2-2 and in Figure 2-2. 

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