5-Methylamino

W-1,3,4-Selenadiazoline-2-selone, 5-methylamino- C NMR, 6. 356 <77JOC3725> 3W-l,3,4-Selenadiazoline-2-selone, 5-p-tolylamino- C NMR, 6, 356 <77JOC3725) 3W-l,3,4-Selenadiazoline-2-thione, 5-p-tolylamino- C NMR, 6, 356 <77JOC3725>... 

Imidazole-4-carboxylic acid, 5-methylamino-ethyl ester thermolysis, 4, 438 Imidazolecarboxylic acids decarboxylation, 5, 434—435 reactions, 5, 92, 434—435 Imidazolediazonium fluoroborates reactions, 5, 439 Imidazolediazonium salts reactions... 

Pyridine-2,3,6-trione, 4-chloro-5-methylamino-monohydrate structure, 2, 114 Pyridinium N-acylimines thermolysis, 2, 345... 

Comparison of the UV speetra of 5-amino-2-(2-furyl)-l,2,4-triazolo[l,5-cjquinazolines (196) and its 5-methylamino derivative (197) in neutral, aeidie, and basie media with the speetra of the two tautomerieally looked derivatives—2-(2-furyl)-5-dimethylamino-l,2,4-triazolo[l,5-c]quinazolines (198) (amino-loeked tautomers) and the imino-loeked tautomers 2-(2-furyl)-5-imino-6-methyl-l,2,4-triazolo[l,5-c]quinazolines (199)—indieated that eompounds 196 and 197 are best represented as a mixture of their amino and imino tautomers (88JMC1014) (Seheme 75). 

Chemical Name 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl] -benzoic acid Common Name —... 

C]7H24N20, 2378-95-2) see Methotrexate diethyl Ai-(5-methylamino-2-thenoyl)-L-glutamate (C15H22N2O5S 112889-02-8) see Raltitrexed diethyl (l-methylbutyl)malonate (C12H22O4 117-47-5) see Secobarbital diethyl methylmalonate... 

C15H19N305S HCI 2, 3 -0-Isopropylidene-5-(methylamino)methyl-2-thiouridine hydrochloride836... 

CuHnNaOaS-BHaO 2-Thio-5-(methylamino)methyluridine, dihydrate TM AMUR 10 43 290... 

Incorporation of Selenium into 2-Selenouridine (Se U) and 5-[(methylamino)-methyl]-... 

Chemical/Physical. Aminocarb was hydrolyzed in purified water to 4-(dimethylamin-o)-3-methylphenol before yielding o-methylbenzoquinone. This compound then oxidized to 6-(di-methylamino)-2-methyl-1,4-benzoquinone, 6-(methylamino)-2-methyl-l,4-benzoquinone, 5-(di-methylamino)-2-methyl-1,4-benzoquinone, and 5-(methylamino)-2-methyl-l,4-benzoquinone... 

If the quaternary nitrogen is a member of a ring, the ring is cleaved. 3-Benzyl-2-phenyl-A, A -dimethylpyrrolidinium chloride was cleaved by hydrogenation over Raney nickel at 20-25° almost quantitatively to 2-benzyl-4-dimethylamino-l-phenylbutane [722]. Reduction of methylpyridinium iodide (and its methyl homologs) with sodium aluminum hydride gave 24-89% yields of 5-methylamino-l,3-pentadiene (and its methyl homologs) in addition to A -methyl dihydro- and tetrahydropyridine [448]. 

Amides of keto acids were reduced to amides of hydroxy acids biochemically using Saccharomyces cerevisiae to give optically pure products [7059]. Refluxing with lithium aluminum hydride in ether for 6 hours reduced both the ketonic and the amidic carbonyl in A -methyl-5-phenyl-5-oxopentanamide and gave 82% yield of 5-methylamino-l-phenylpentanol [1134]. 

The triacyl compound (30) is obtained when an excess of benzoyl chloride is used in the acylation of 3-amino-5-methylamino-l,2,4-thiadiazole (29). However, when acetic anhydride is used no ring nitrogen acylated product is obtained <84CHEC-i(6)463>. Acetylation of 3-hydroxy-5-phenyl-1,2,4-thiadiazole (23) with acetic anhydride and dbu at room temperature gives a small amount of the N-2 compound (28) (Equation (6)) <85JHC1497>. 

Distortion of the chair conformation by substitution occurs in 2,2,6,6-tetramethyl-piperidin-4-one hydrochloride (45) (71AX(B)932), in which steric interaction between axial methyl groups leads to flattening of the ring. The resultant C(2)—C(6) intramolecular distance is 3.2 A, to be contrasted with 2.4 A in the non-methylated compound. A similar effect is to be found in other 2,2,6,6-tetramethyl derivatives (81AX(B)1771). In the related free radical nitroxide (46) the steric interactions are reduced by adoption of a symmetric twist chair form (74AX(B)790). 4-Chloro-5-methylamino-2,3,6-pyridinetrione monohydrate... 

Dimethoxy-l-methyl-azepan setzt sich mit Benzoesaure-amid-hydroximid entsprechend zu 5-(5-Methylamino-pentyl)-3-phenyl-1,2,4-oxadiazol [72% Sdp. 138—141 °/0,l Torr (13,3 Pa)]... 

---