1- Amino-2-methylamino

In principle, aminopyrazine and 2-aminoquinoxaline are capable of existing in the form of the imino tautomers (81) and (82) however, comparison of the UV spectra of the amino, methylamino and dimethylamino derivatives indicates that in both systems the amino rather than the imino tautomer is favored (60JCS242, 58JCS108). 

A widely used approach is the condensation of (amino, methylamino, or ethyl-amino)benzohydrazides 73a with ethyl 3-oxobutanoate in boiling ethanol... 

Electron-donating groups (amino, methylamino, hydroxy, methoxy) in the 2-position, on the other hand, are extremely undesirable because, unlike similar substituents in the 1,4-positions, they are unable to form intramolecular hydrogen bonds with the keto groups of anthraquinone and hence are highly susceptible to photo-oxidation [167]. 

Trimethyl(trifluoromcthyl)siIanc is easily fluorodesilylated by tris(dimethyIamino)suIfonium difluorotrimethylsilicate [TASF(Me)], tetrabutylammonium fluoride, or tris(diethylamino) (methylamino)phosphonium hydrogen difluoride and, if arenesiilfonyl fluorides are used to trap the trifluoromethyl anion, trifluoromethyl sulfones are formed in high yield. Trisfdiethyl-amino)(methylamino)phosphonium phenolate is also an effective catalyst for this reaction, but TASF(Me) is favored as it can achieve the quantitative transformation of ArSOjF into aryl trifluoromethyl sulfones. ... 

Z)-3-(Amino-methylamino-methylen)-2-oxo-tetrahydro-E15/2, 2102 (2-NH2 —3-COOR —4,5-H2 —furan + R—NH2) (3R)-3-Amino-2-oxo-tetrahydro- Hydrochloride E21a, 1052 [RO —CRJR2 CHR3 — CR+(NH2)-COOCH3 + H ]... 

Amino-methylamino-methylen)- -methylester-nitril EI5/2, 2155 (CC13 ->NH —R) (Diamino-methylen)- -ethylester-nitril E15/2, 2156 (CC13 NH2)... 

Malonsaure (Amino-methylamino-methylen)- -dimethylester E15/2, 2153 (CC13 - NH2), 2155 (CCIj-NH2)... 

Booth H, Jozefowicz ML (1976) The application of low temperature C nuclear magnetic resonance spectroscopy to the determination of the a-values of amino-, methylamino-, and dimethylamino-substituents in cyclohexane. J Chem Soc Perkin Trans 2 895-901... 

Se under A -Methylphenylenediamine. Amino-methylamino-valeric Acid. 

Example Miller and Rich investigated the conformational consequences of substitution s on an amino acid in cyclosporin A. an importan t iininunosnppressive dnig. One of th e ammo acids iii this cyclic iin decapeptide is (2.v, ir. 4r, 5f )-3-nydroxy-4-methyl-2-(methylamino)-6-octenoic acid (MeBmtli. It is essential for biological activitv. 

CA name (R)-(-)-4-[l-hydroxy-2-(methylamino)eth5l]-1,2-benze nediol (R)-(-)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol... 

The basic piSTa values, which have to be considered as equilibrium values, including those of anhydrous and hydrated species, reveal a destabilizing inductive effect of the 6- and 7-methyl group towards 3,4-hydrate formation, as do also the 2-methylamino and 2-dimethylamino groups for additional steric reasons. If the cation of 2-aminopteridine did not add water its value would be about 1.6, arrived at by substracting from the piSTa 2.6 of the essentially anhydrous 2-amino-4,7-dimethylpteridine cation 0.3 for the 7- and 0.7 for the 4-methyl group. The difference between the observed value of 4.29 and the... 

The alkylthio group is replaceable by nucleophiles. The positions 7 and 4 react under mild conditions in that order the 2-alkylthio functions require more drastic treatment. Conversion of l-methyl-4-methylthiopteridin-2-one (157) into the 4-methylamino derivative (158) can be achieved by stirring with methylamine at room temperature (equation 48). The reactivity of an alkylthio group can often be further enhanced by oxidation to the corresponding sulfoxide and sulfone. Thus, reaction of l,3-dimethyl-7-methylthiolumazine (160) with m-chloroperbenzoic acid yields 7-methylsulfinyl- (161) and 7-methylsulfonyl-l,3-dimethyllumazine (162 equation 49) (82UP21601). 4-Amino-2-methylthio-7-... 

Butyric acid, 2-amino-4-(4-carboxythiazol-2-yl)-occurrence, 6, 327 Butyric acid, 4-(indol-3-yl)-as plant growth regulator, 1, 191 Butyric acid, y-(3-pyridyl)-y-methylamino-as metabolite... 

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