5-methyl-2-methylamino-4-phenyl

CASRN 2032-59-9 molecular formula C11H16N2O2 FW 208.26 Plant/Surface Water. Several transformation products reported by Day (1991) include 4-amino-/n-tolyl-7V-methylcarbamate (AA), 4-amino-3-methylphenol (AC), 4-formamido-/n-tolyl-TV-methylcarbamate (FA), 7V-(4-hydroxy-2-methylphenyl)-yV-methylformamide (FC), 4-methyl-formamido-/n-tolyl-7V-methylcarbamate (MFA), 4-methylamino-/n-tolyl-Wmethylcarbamate (MAA), 3-methyl-4-(methylamino)phenyl-Wmethylcarbamate (MAC), phenol, methylamine, and carbon dioxide. MAA was not detected in natural water but was detected in fish tissues following exposure to aminocarb-treated water in the laboratory. The metabolites FA, AC, and MAC were detected in Canadian forests treated with aminocarb but the metabolites AA, MAA, and FC were not detected (Day, 1991). 

Amides of keto acids were reduced to amides of hydroxy acids biochemically using Saccharomyces cerevisiae to give optically pure products [7059]. Refluxing with lithium aluminum hydride in ether for 6 hours reduced both the ketonic and the amidic carbonyl in A -methyl-5-phenyl-5-oxopentanamide and gave 82% yield of 5-methylamino-l-phenylpentanol [1134]. 

Diazepam From a chemical point of view, diazepam, 7-chloro-l,3-dihydro-l-methyl-5-phenyl-2H-l,4-benzodiazepin-2-one (5.1.2), is the most simple of all of the examined derivatives of l,4-benzodiazepin-2-ones. Various ways for the synthesis of diazepam from 2-amino-5-chlorobenzophenone have been proposed. The first two ways consist of the direct cyclocondensation of 2-amino-5-chlorobenzophenone or 2-methylamino-5-chlorobenzophenone with the ethyl ester of glycine hydrochloride. The amide nitrogen atom of the obtained 7-chloro-l,3-dihydro-5-phenyl-2H-l,4-benzodiazepin-2-one (5.1.1), is methylated by dimethylsulfate, which leads to the formation of diazepam (5.1.2). 

Methylamino-6-methylcarbamoyl-2-pyrazinecarboxylic acid Methyl 3-amino-5-methyl-6-phenyl-2-pyrazinecarboxylate Methyl 3-amino-6-methyl-5-phenyl-2-pyrazinecarboxylate 3-Methylaminomethyl-2-pyrazinamine Methyl 3-amino-5-methyl-2-pyrazinecarboxylate Methyl 3-amino-6-methyl-2-pyrazinecarboxylate Methyl 3-amino-5-methylsulfinyl-2-pyrazinecarboxylate... 

Thus, 2-imino-3-methyl-5-phenyl-l,3,4-oxadiazoline is obtained from the methylation of 2-amino-5-phenyl-l,3,4-oxadiazole with methyl iodide.61,63 Only in a sealed tube with an excess of methyl iodide is 2-methylimino-3-methyl-5-phenyl-1,3,4-oxadiazoline formed.63 The structure of the alkylated product was confirmed by its nonidentity with 2-methylamino-5-phenyl-l,3,4-oxadiazole or 2-dimethylamino-5-phenyl-l,3,4-oxadiazole which were synthesized by an independent route. 

A ring contraction occurs during the reduction of 7-chloro-2-methylamino-5-phenyl-3 -4,5-dihydro-l, 4-benzodiazepine (99) to 6-chloro-2-methyl-4-phenyl-3,4-dihydroquinazoline (100)." It has been suggested that the reaction takes the course shown in Scheme 12,61 but another interpretation has also been offered."... 

Methyl-1-phenyl- E4, 492 (ROOC —NCS + Amin) Thiophen 3-Cyan-4,5-dimethy]-2-methylamino- IV/ld, 351... 

Adamantan 1-Acetamino- E5, 995 (Umaminier.), 1032/1034 (H - NH-Ac), 1037 (OH - NH-AC) l-Aza-spiro 4.5 dec-6-en 7-Methoxy-l-methyl-3-methylen- E19a, 768 (Cycloaddition/Desilylierung) 3H-Azepin 2-Hexyloxy- E9d, 158 (02N —Ar + R3P R —OH) Azetidin l-Cyclohexyl-4-ethyl-3-methylen-2-oxo- E16b, 136 (aus HO-A-CO-NHR) Butanol 2-(Methylamino-methyl)-2-phenyl- IV/ld, 133... 

CHLORO-2-METHYLAMINO-5-PHENYL-3H-1.4-BENZODIAZEPIN 4-OXIDE 7-CHLORO-N-METHYL-5-PHENYL-3H-l,4-BENZODIAZEPIN-2-AMINE-4-OXIDE... 

Mono Q Chromatography - For the purification of recoverin, fractions from the phenyl-Sepharose eluate containing protein are combined and dialyzed against 10 mM l,3-bis[tris(hydroxy-methyl)methylamino]propane (BIT) buffer, pH 8.4 containing 1 mM EDTA. i iquots are applied to a Mono Q column (HR 5 x 50 mm Pharmacia Fine Chemicals) equilibrated with the same buffer. A linear gradient of NaCl (0-0.25M NaCl) in the same buffer is developed over 20 min at a rate of 0.5 ml/min, and recoverin elutes at 125 mM NaCl. Approximately 1 mg of purified recoverin is obtained per fifty retinas. 

Both 1,4- [340-342] and 1,5-benzodiazepines [343] are polarographically reducible the latter is somewhat unstable in aqueous solution, which complicates the investigations. 1,4-Benzodiazepines like 7-chloro-2-methylamino-5-phenyl-3i7-l,4-diazepine-4-oxide are reducible in acid solution in three steps. The first two steps, the reduction of the A -oxide and the saturation of the benzophenone imine, are straightforward. The mechanism of the third step, a reductive ring contraction to 6-chloro-2-methyl-4-phenyl-3,4-dihydroquina-zoline, is more controversial [51, 157]. 

Diethoxyphosphoryl-l-hydroxy-ethyl)-4-methyl-2-methylamino- 202 5-(2-Diethoxyphosphoryl-l-hydroxy-propyl)-4-methyl-2-phenyl- 202... 

---