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2-Methyl-5-pyridinecarboxylic acid

Pyridine 210 is oxidized by 20% nitric acid at the acetyl group to 2-methyl-5-pyridinecarboxylic acid, while its ozonation gives cinchomeronic acid [pyridine-2,5-dicarboxylic acid (215)] (75DIS) which is decarboxylated (200°C, 2 h) to nicotinic acid 216 in 97% yield (75DIS). [Pg.212]

As the reactivity of a function group depends on the structure of the molecule as a whole, and particularly on the nearest neighbours, the reaction used and the reaction conditions in the determination of a functional group depend on the type of compound. Thus, several methods of methylating pyridinecarboxylic acids have been compared... [Pg.289]

Chemical Name 3-pyridinecarboxylic acid 2,2-bis[[(3-pyridinylcarbonyl)oxy] methyl]-1,3-propanediyl ester... [Pg.1071]

Niacin methyl ester nicometh 3-carbomethoxypyridine methyl 3-pyridinecarboxylate 3-pyridinecarboxylic acid methyl ester... [Pg.188]

CN 3-pyridinecarboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-l-oxopropoxy]ethyl ester... [Pg.814]

RN 70-19-9 MF Ci.HijNOj MW 207.23 EINECS 200-727-5 CN 3-pyridinecarboxylic acid (tetrahydro-2-furanyl)methyl ester... [Pg.1430]

A bicyclic urea (123) was an unexpected product of the reaction between pyrrolidine and the phenyl ester of 2-cyano-l,4,5,6-tetrahydro-l-pyridinecarboxylic acid (124 R = Ph) the corresponding methyl ester (124 R = Me) reacted, as expected, to give the product of Michael addition (125). ° The better leaving ability of phenoxide vs methoxide presumably tilted the reaction towards the substitution rather than the addition product, although thiols (e.g. PhSH) underwent only the addition reaction. [Pg.56]

Oxidation of methylpyridines in 60-80 % sulphuric acid at a lead dioxide anode leads to the pyridinecarboxylic acid [213]. The sulphuric acid concentration is critical and little of the product is formed in dilute sulphuric acid [214]. In these reactions, electron loss from the n-system is driven by concerted cleavage of a carbon-hydrogen bond in the methyl substituent. This leaves a pyridylmethyl radical, which is then further oxidised to the acid, fhe procedure is run on a technical scale in a divided cell to give the pyridinecarboxylic acid in 80 % yields [215]. Oxida-tionof quinoline under the same conditions leads to pyridine-2,3-dicarboxylic acid [214, 216]. 3-HaIoquino ines afford the 5-halopyridine-2,3-dicarboxylic acid [217]. Quinoxaline is converted to pyrazine-2,3-dicarboxylic acid by oxidation at a copper anode in aqueous sodium hydroxide containing potassium permanganate [218]. [Pg.228]

Streptonegrin (negrin, 5-amino-6-[7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl]-4-[2-hydroxy-3,4-dimethoxyphenyl]-3-methyl-2-pyridinecarboxylic acid) [3930-19-6] M 506.5, m 262-263°, 275°(dec). Purified by TLC on pH 7-buffered silica gel (made from a slurry of Silica Gel 60 and 4(X)ml of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHClj. The extracted band can then be recrystd from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCOy (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has a pKa value in the range 6.2-6.4 (dioxane/H2O 1 1) and UV 248, 375-380nm (e 38400 and 17400). [Weinreb et al. JACS 104 536 1982 Rao et al. JACS 85 2532 1963]. It is an antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 7967]. [Pg.513]

Acetonyl-3-pyridinecarboxylic acid (75) gave 7-methyl-1,6-naphthyridin-5(6Z/)-one (76) (NH4OH, reflux, 18 h 80% analogs likewise).1072... [Pg.77]

Methyl-3-pyridinecarboxylic acid (92) with propionitrile gave 7-ethyl-1,6-naphthyridin-5(6//)-one (93) [Et2NNa (made in situ), THE, A synthon/THFJ, dropwise, —78°C, then 20°C, 24 h 35%] 7-propyl homolog (50%) similarly.131... [Pg.79]

Ethoxycarbonylmethyl-3-pyridinecarboxylic acid (99) with a Vilsmeier reagent (made in situ) gave 6-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carboxylic acid (100) (substrate, Me2NCHO, POCI3, 0°C, 1 h, then 95°C, 6 h 69% note the hydrolysis of the ester grouping).876... [Pg.80]

CN 3-pyridinecarboxylic acid 3-[2-f4-chlorophenoxy)-2-methyl-1 -oxopropoxy]propyl ester hydrochloride... [Pg.1836]

Arecaidine (= Arecaine 1,2,5,6-Tetrahydro-1 -methyl-3-pyridinecarboxylic acid) (piperidine)... [Pg.240]

Pyridine aldoxime methiodide, 915 Pyridine aldoxime methochloride, 915 Pyridine aldoxime methyl mesylate, 915 Pyridinecarboxamide, 807 Pyridinecarboxylic acid, 808 Pyridinemethanol, 809... [Pg.1564]

C7H6CIN02 2-chloro-6-methyl-3-pyridinecarboxylic acid 30529-70-5 40.00 1.3576 2 10374 C7H6N204 dinitrotoluene 25321-14-6 25.00 1.3210 1... [Pg.229]

C6H5N02 3-pyridinecarboxylic acid 59-67-6 in benzene 2.530 1 8412 C6H120 4-methyl-2-pentanone 108-10-1 in benzene 2.689 1... [Pg.676]

Nitrendipine. Nitrendipine. l.4-dihydro-2.6-dimethyl-4-(3-nitrophcnyl)-3.5-pyridinecarboxylic acid methyl ethyl... [Pg.632]

See other pages where 2-Methyl-5-pyridinecarboxylic acid is mentioned: [Pg.568]    [Pg.5]    [Pg.245]    [Pg.246]    [Pg.1002]    [Pg.207]    [Pg.225]    [Pg.10]    [Pg.37]    [Pg.38]    [Pg.224]    [Pg.58]    [Pg.63]    [Pg.225]    [Pg.223]    [Pg.272]    [Pg.247]    [Pg.631]    [Pg.699]   
See also in sourсe #XX -- [ Pg.82 , Pg.212 ]

See also in sourсe #XX -- [ Pg.82 , Pg.212 ]



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3- Pyridinecarboxylic acid, methyl ester

Pyridinecarboxylic acids

Tetrahydro-methyl-pyridinecarboxylic acid

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