1- Methyl-3-phenyl-5- -pyridinone

Two papers deserve to be reported here. The absence of excited-state intramolecular proton-transfer (ESIPT) in 3-hydroxy-2-methyl-phenyl-4-pyridinone (129) was explained by the twist (48°) of the dihedral angle (AMI calculations) (94CPL(220)229). The tiimethyl derivative of N-(l-naphthyl)-pyridinium 130 shows temperature dependent multiple fluorescence. B3LYP/6-31G(d) calculations indicate that several minima on the SI-hypersurface are responsible for this behavior (01MI127). 

Despite their importance in many pharmacological uses and potential applications, solubilities of hydroxypyranones, hydroxypyridinones, and their complexes have not been extensively and systematically investigated and established. This situation contrasts sharply with that for partition coefficients, as will become apparent in the following section. The solubility of maltol in water is approximately 0.1moldm , of ethyl maltol 0.13 mol dm, at 298 K. 1,2-Alkyl-3-hydroxy-4-pyridinones show the expected decrease in water-solubility as the sizes of the alkyl groups increase solubilities - in water at 298 K - of l-aryl-2-methyl-3-hydroxy-4-pyridinones decrease from 9 X 10 mol dm for the 1-phenyl compound through 6 x lO- moldm for l-(4 -tolyl) to 6 x 10 mol dm for l-(4 -re-hexyl-phenyl) (37). 

Chemical Name l-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl] 4(lH)-pyridinone 1-methyl-3-phenyl-5-(a , or-trifluoro-m-tolyl)-4-pyridone... 

The course of the cyclization of amino (or acylamino) ketones to pyrido[2,3-phenyl group is replaced by 2-fluorophenyl. Under mildly alkaline conditions, the amino and fluoro functions react to form a sandwiched 4-pyridinone ring. This compound is methylated (Mel-NaH-DMF) at N-2. A side-chain amino group which may be regarded as a vinylogous carboxamide displaces a bz-fluorine atom on heating with sodium hydride. 

Dihydro-5-methyl-6-phenyl-2(lFf)-pyridinone (26) Typical Procedure133 ... 

Methyl-3-phenyl-5-[ trifluoromethyl)phenyl])-4 (1 H )-pyridinone 4 Amino--6-tert-butyl-3-(methylthio)-as-triazin-5(4 H )one... 

Fluridone. See 1-Methyl-3-phenyl-5-[3-(trifluoromethyl) phenyl]-4(1H)-pyridinone Fluroxypyr CAS 81406-37-3... 

Isopropanolamine 2-Mercaptoethanol 1-Methyl-3-phenyl-5-[3-(trifluoromethyl) phenyi]-4(1 H)-pyridinone a-Naphthylamine Nitrosophenylhydroxylamine ammonium salt Phenyl benzoate m-Phenylenedimaleimide N-Phenylmaleimide Phenyl mercuric bromide Potassium carbonate Potassium N-hydroxymethyl-N-methyldithiocarbamate Pyridine Silica, fused Tetrachlorophthalic acid Thiourea p-Toluic acid , N-Tridecyl-2,6-dimethylmorpholine Trimethyl phosphate agric. chemicals, maleic hydrazide Hydrazine agric. sprays Zinc sulfate monohydrate agric., biodegradable Poly (hydroxybutyrate-hydroxyvalerate) agriculture... 

Hydroxy-2-methyl-1 -phenyl-4( 1 //)-pyridinone, H-00315 7V-Hydroxy-A -(4-methylphenyl) tetradecanamide, H-00316 A -Hydroxy-7V-(3-methylphenyl)-3-(2-thienyl)-2-propenamide, in H-00553 A -Hydroxy-7V-(4-methylphenyl)-3-(2-thienyl)-2-propenamide, in H-00553... 

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