Methylphenyl ketone

C5H10B1O4P) see Penciclovir 4-bromomethyl-S-methyl-2-oxo-l -dioxole (C5H5Br03 80715-22-6) see Lenampicillin bnimometbyl 4-methylphenyl ketone (CjtljBiO 619-41-0) see Zolpidem... 

Methyl 2-methyl phenyl ketone, AP28 Methyl 3-methyl phenyl ketone, AP29 Methyl -methylphenyl ketone, AP30 Methyl 2-methylpropenoate, AE51 2-Methyl-2-methylthi opropion-aldehyde, AE73... 

To a suspension of KF (0.19 g,2.0 mmol) in DMI (10 ml) was added difluoro(ethyl) (4-methylphenyl)silane (0.56 g, 3.0 mmol) under 1 atm of carbon monoxide (balloon). After stirring at room temperature for 10 min, the reaction mixture was heated at 100 °C for 3 h. Bulk of the solvent and the catalyst were removed by passing the mixture through a silica gel column with ethyl acetate-hexane = 1 10 as an eluent solvent. Evaporation of the solvent under reduced pressure afforded 4-acetylphenyl 4-methylphenyl ketone (0.43 g, 91% yield) as a colorless solid. 

Acyl chlorides react with aromatic hydrocarbons in the presence o aluminium chloride. The reaction furnishes a convenient method of preparing ketones. The preparation of methylphenyl ketone is an example —... 

K. M. (2000) Discovery of a novel dopamine transporter inhibitor, 4-hydroy-1 -methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling. Stracture-activity relationships, and behavioral pharmacological studies. J. Med. Chem. 43 351-360. 

Condensation of o-aminobenzaldehyde cyanohydrin and methylphenyl ketone yields dnchophen. Method-II From Isatin... 

Assignment based on radicals from dj-phenyl 2-methylphenyl ketone, 2-methylphenyl 4 -t-butylphenyl ketone and 2-methylphpnyl 3 -chlorophenyl ketone. 7 ) Discussion of conformation (ortho-substituted phenyl group bent out of plane of the three central bonds). 

Methyl 2-methylsulfinyl-5-methylphenyl ketone allowed to react 15 hrs. with NaNg and sulfuric acid in chloroform -> l,3,6-trimethyl-l,2,4-benzothia(VI)diazine 1-oxide. Y 77%. T. R. Williams and D. J. Cram, J. Org. Chem. 38, 20 (1973). 

Steroids.—Intramolecular Diels-Alder reactions of o-quinodimethanes, generated by thermolysis of the corresponding benzocyclobutanes, continue to form the basis of many steroid syntheses, " including estradiol derivatives, 18-hydroxyestrone, (+)-chenodeoxycholic acid, and des-A-ring steroids. Two alternative ways to obtain o-quinodimethanes, by photoenolization of o-methylphenyl ketones or by a fluoride-ion-induced elimination reaction [(191)- (192)1, have been utilized in syntheses of 19-nor-steroids and O-methyl estrone (193), respectively. 

Benzoic acid amide 591 Biallyl 5779 Bis(4-methylphenyl) ketone 3968... 

---