3- Methyl-5-nitro-4-phenyl

Benzothiazole, 2-methyl-2-phenyl-2,3-dihydro-synthesis, 6, 325 Benzothiazole, 2-nitro-reactions, 6, 285 Benzothiazole, 5-nitro-nucleophilic attack, 5, 62 reactions... 

Imidazole, 1 -methyl-5-nitro-2-styryl-ozonolysis, 5, 437 Imidazole, l-methyl-2-phenyl- C NMR, 5, 354 Imidazole, l-methyl-4-phenyl- C NMR, 5, 355 Imidazole, 2-methyl-4-phenyl-acylation, 5, 402... 

Isoxazoline, 5-methyl-3-phenyl-quatemization, 6, 39 2-Isoxazoline, 3-nitro-... 

Thiophene, 3-methyl-4-phenyl-phototranspositions, 4, 743 Thiophene, 2-(methylthio)-3,4-disubstituted synthesis, 4, 876, 931 Thiophene, nitro-... 

Uracil, 5-methoxy-6-methoxymethyl-2-thio-synthesis, 3, 134 Uracil, 1-methyl-aminolysis, 3, 91 synthesis, 3, 110 Uracil, l-methyl-5,6-dihydro-synthesis, 3, 110 Uracil, 6-methyl-3-phenyl-synthesis, 3, 110 Uracil, 3-methyi-2-thio-synthesis, 3, 112 Uracil, 6-methyl-2-thio-oxidation, 3, 94 Uracil, 5-nitro-... 

Melles and Backer " found, from a study of the oxidation of substituted thiophenes with perbenzoic or peracetic acid, that sulfones could be obtained from polysubstituted methyl- and phenyl-thiophenes and that the presence of electron-attracting groups, such as nitro, hindered the oxidation. Oxidation of thiophene - led to a product which was formed through a Diels-Alder reaction between the intermediate thiophene sulfoxide (211) and thiophene sulfone (212) and for which two alternative structures, (213) or (214), were suggested. Similar sesquioxides were also obtained from 2- and 3-methylthiophene and 3-phenylthiophene. The structures were not proved. Bailey and Cummins synthesized thiophene-1,1-dioxide... 

A solution of N-(2-aminobenzvl)-1-phenyl-2-metKylaminoethanol-1 was prepared by the reaction of a-bromo-acetophenone and (2-nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickei on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. Dy extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-iso-quinoline. The base is reacted with maleic acid to give the maleate melting point of the maleate 199° to 201°C (from ethanol). 

Picrolonic Acid [l-(4-Nitro-phenyl)-4 nitro-3-methyl-Pyrazolone-(5)]. 

Bis-[4-mcthoxy-bcnzyl]- 414 Bis-[4-methoxy-phenyl]- 372 Bis-[2-nitro-phenyl]- 474 Bis-[2-phenyl-2-cyan-vinyl]- 676 Bis-[tetrahydrothienyl-(2)J-methyl]- 99 Diathyl-... 

Dimcthyl-(4-methyl-phenyl)- 283, 286, 288 Dimethyl-(4-nitro-phenyl)- 238 Dimethyl-nonyl- 358 Dimethyl-phenyl- 130, 537, 698... 

Meibyl-phenyl)-(4-methyl-benzy1iden)- 664 Methyl-propyl-phenyl- 361 Methyl-(2,2,2-trifluor-athyl)- 239 Methyl-undecyl- 130 N-Nitro- 3641, 4791, 489 (4-Nitro-benzyl)- 116, 377 N-Nitroso- 479/., 696/. 

Methyl-2-( 1-hydroxy-cyclohexyl)- 520 2-Nitro-1-phenyl- 559 2-(2-Nitro-phenyl)- 698... 

Methyl-phenyIthio)-(4-nitro-phenyl)- 700 (2-Nitro-phcnyl)-(2-hydroxy-5-methyl-phenyl)- 693 (2-Nitro-phenyl)-(4-methoxy-phenyl)- 693 (2-Nitro-phenyl)-(4-methyl-phenyl)- 693 Phenyl-(4-amino-phenyl)- 568 Ph en yl-(4-formyl-phenyl) -... 

N-Diphenylmethylen- 374 N-Diphenylmethylen-O-aminocarbonyl- 612 N-[l,3-Diphenyl-propyl-(2) - 374 N-[l,3-Diphenyl-propyliden-(2)]- 374, 377, 380 N-(4-Halogen-phenyI)- 683 N-Heptyl- 375 N-Heptyl-N-acetyl- 376 N-Heptyliden- 375 N-Hcptyliden-O-acetyl- 376 0-(2-Hydroxy-athyl)-N-athoxycarbonyl- 133 N-(4-Hydroxy-phenyl)- 683 0-(2-Hydroxy-l-phenyl-athyI)-N-athoxycarbonyI-aus 0-(ci-AthoxycarbonyI-benzyl)-N-athoxycar-bonyl-hydroxylamin und Lithiumalanat 133 N-Isopropyl- 682 N-Isopropylidcn- 613 N-Methyl- 133, 682 O-Methyl-N-bcnzyliden- 377 O-Methyl-N-benzyliden- 375 0-Methyl-N-(4-chlor-benzyl)- 375 0-Methyl-N-(4-chlor-benzyliden)- 375 N-Methy -N,0-diacetyI- 682 N-(4-Methyl-phenyl)- 683 0-McthyI-N-( 1 -phenyl-athyliden)- 375 N-(4-Methylthio-phenyl)- 684 N-(4-Nitro-benzyl)- 374 N-[4-Nitro-benzyliden - 374, 377 N-(2-Nitro-phenyl)- 562 N-(4-Nitro-phenyl)- 682 N-Nitroso-N-cyclohexyl- 697 N-Octyl- 374 N-Octyl-(2)-N-acetyl- 376 N-Octyliden- 374 N-0ctyliden-(2)-0-acctyl- 376 N-(Pentafluor-phenyl)-0,N-diacetyl- 697 N-Phenyl- 474, 481, 682, 783 N-Phenylacetyl-O-benzoyl- 265 N-(l-Phenyl-athyl)- 374 N-(l-Phenyl-athyl)-N-acetyl- 376 N-(l-Phenyl-athyliden)-374, 613 N-( l-Phenyl-athyliden)-0-acetyl- 376 N-[ 1 -Phenyl-buten-( 1 )-yl-(3)-iden]- 582 N-f4-Phenyl-butyl-(2)-iden]- 581 N-Phcnyl-N,0-diacetyl- 682 N-(4-Phenylthio-phenyl)- 684 N-Propyl-N-cyclohexyl- 376 N-Propyl-N-isopropyl- 376 O-Sulfonyl- 481 N-(4-Sulfonyl-phenyI)- 683 N-(2-Vinyl-phenyl)- 698... 

Amino-3-athoxy-l-phenyl-erythro- 325 2-Amino-2-methyl- 163 2-Amino-3-oxo-3-(4-nitro-phenyl)- 782... 

AthyI-(4-amino-phcnyl)- 684 Athyl-benzyl- 500 Bis-[4-brom-phenyI]- 572 Bis-[4-chlor-phenyl]- 488 Bis-[4-hydroxy-phenyl]- 572 Bis-14-methoxy-phenyl]- 572 Bis-[4-methyl-phenyl]- 572 Bis-[4-nitro-phenyl]- 572 a-Brom- 534f. 

Acetyl-phenyl- 635 4-Amino-3,5-dimethyl-phenyl- 102 2-Amino-4-hydroxy-phenyl- 692 4-Amino-phenyl- 685 4-Benzylamino-phenyl- 102 2,4-Dinitro-phenyl- 692 4-(2-Hydroxy-benzylamino)-phenyl- 102 2-(2-Methyl-butanoyl)-phenyl- 635 4-Methoxy-2,6-dimethyl-phenyl-102 (Nitro-phenyl)- 635 2-Nitro-phenyl- 680, 692 4-Nitro-phenyl- 685... 

Methyl-2-propyl-4,5-dihydro- 701 5-Methyl-2-(trimethylammoniono-methyl)-3-(4-chlor-3-nitro-phenyl)-4-athoxycarbonyl- 454 1 -Nitroso-4-methyl-2-phenyl-2,5-dihydro- 480... 

Fig. 23 A plot of the observed pseudo-first-order rate constant for the methanolysis of 0.04mM HPNPP ( , left axis) catalyzed by 0.2mM35 2Zn(II) or 0.04mM methyl /j-nitro-phenyl phosphate (O, right axis) catalyzed by 0.4 mM 35 Zn(II) as a function of the [CH30-]/ [35 Zn(II)] ratio at 25 + 0.1 °C. Experiments done by pH jump method starting at a [CH30-]/ [35 Zn(II)] ratio of 1.0 (vertical dashed line, (pH = 9.5) and adding acid (left) or base (right). Reproduced with permission from ref. 95.

T. M. Kitson, The Action of Cytoplasmic Aldehyde Dehydrogenase on Methyl p-Nitro-phenyl Carbonate and p-Nitrophenyl Dimethylcarbamate , Biochem. J. 1989, 257, 579-584 T. M. Kitson, K. E. Kitson, A Comparison of Nitrophenyl Esters and Lactones as Substrates of Cytosolic Aldehyde Dehydrogenase , Biochem. J. 1996, 316, 225-232 T. M. Kitson, K. E. Kitson, Studies of the Esterase Activity of Cytosolic Aldehyde Dehydrogenase with Resorufin Acetate as Substrate , Biochem. J. 1997, 322, 701-708. 

Unsubstituted cycloamyloses have been used to catalyze a number of reactions in addition to acyl group transfer. Brass and Bender (8) showed that cycloamyloses promoted phenol release from diphenyl and bis(p-nitro-phenyl) carbonates and from diphenyl and bis(m-nitrophenyl)methyl phos-phonates. Breslow and Campbell (10,11) showed that the reaction of anisole with HOCL in aqueous solution is catalyzed by cyclohexaamylose and cycloheptaamylose. Anisole is bound by the cyclodextrins and is chlorinated exclusively in the para position while bound. Cycloheptaamylose has been used to promote regiospecific alkylation followed by the highly selective oxidation shown in reaction (3) (95). In addition cycloheptaamylose effec-... 

Only two examples of the synthesis pyrimidoazocines have been described. In Ref. 82JHC1257, a three-stage synthesis of a new heterocycle system, pyrimido[5,4-c]benz[l]azocine, has been proposed. Condensation of 4-methyl-2-phenyl-5-pyrimidincarboxylate (112) with 3,4-dimethoxy-6-nitrobenzaldehyde (113) led to the substituted alkene 114, which, after catalytic hydrogenation of the nitro group on Raney nickel and subsequent intramolecular cyclization of product 115, was converted into pyrimidobenz[l]azocine 116 (Scheme 32). 

Chemical cleavage at selective amino acid residues is an alternative method for scission of peptide bonds in target molecules. Cleavage at the Met-Xaa bond is achieved by CNBr, at the Trp-Xaa bond by the tryptophan-directed reagent 3-bromo-3-methyl-2-[(2-nitro-phenyl)sulfanyl]-3//-indole (BNPS-skatole) and at the Asp-Xaa bond by 2% formic acid.123 24 All these reactions are carried out at acidic pH under standard conditions for each reagent. 

CII, ho7 A.4Hy 1-Butyl-5- (4-chlor-phenyl )-4-methyl-2- (3-nitro-phenyl)-... 77 227a... 

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