3-methyl-4-nitro-phenyl ester hydrolysis

The catalytic effects of poly(3-methyl-l-vinylimidazolium iodide) poly(3-n-hexadecyl-l-vinylimidazolium iodide), and their monomeric analogs on the alkaline hydrolysis of a series of neutral and anionic nitro-phenyl esters were studied in order to elucidate the contribution of hydrophobic and electrostatic interactions to their esterolytic efficiency. 

The synthesis of pyrrolo[2,3- 7 pyridazines can be achieved by starting either with pyridazine, a tetrazine, or a pyrrole. Pyridazinone 80 reacts with bromomethyl derivatives to give poor yields of 81 <1996H(43)1863> (Equation 34), while 5-acetyl-2-methyl-4-nitro-6-phenyl-3(2//)-pyridazinone, after treatment with sarcosine ethyl ester for a brief time at room temperature, followed by acid hydrolysis afforded a good yield of 82 (70%) <1994S669>. 

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