4- Methyl-4-nitro-l-phenyl

Butyl-3,3-dimethyl-2.6-dioxo-EI4a/2, 306 (Keten + Imin) 3-Pentanol 4-Methyl-4-nitro-l-phenyl- E16d, 216 (CH-N02 + R-CHO)... 

Methyl-4-nitro-l-phenyl-5J -bi-( IH-pyrazolyl)1713 77% Schmp. 81—82 (Ethanol/Wasser)... 

Methyl-4-nitro-l -phenyl- 612 3 -Methyl-4 -nitro-l -phenyl- 629 3 -Methyl-4 -nitro-l, 3,5-triphenyl- 431 4 -Nitro- 599... 

Aq. hydrazine added dropwise with stirring below 55° to a mixture of 4-methyl-4-nitro-3-phenyl-l-(3-pyridyl)-l-pentanone and Raney-Ni, stirring continued 2 hrs. 5,5-dimethyl-4-phenyl-2- (3-pyridyl) -Zl -pyrroline 1-oxide. Y 70-75%. F. e. s. M. G. Kloetzel et al.. Am. Soc. 83, 1128 (1961). 

The results of Katritzky and co-workers [74JCS(P2)382], who carried out an extended study of such systems, are shown in Fig. 10. These indicate that all six compounds studied reacted as the conjugate acid at high acidity. Three compounds also reacted as the conjugate acid at low acidity [3-methyl-4-nitro-l-phenylpyrazolin-5-one, 3-methyl-5-methoxy-4-nitro-l-phenyl pyrazole, and 3-methyl-5-methoxy-l-(4-nitrophenyl) pyr-azole]. The other three compounds [2,3-dimethyl-4-nitro-l-phenylpyraz-olin-5-one, 3-methyl-1-(4-nitrophenyl) pyrazolin-5-one, and 2,3-dimethyl-1-(4-nitrophenyl) pyrazolin-5-one] reacted as free bases at low acidity. 

THPROL. Thiamine picrolonate dihydrate thiamine 3-methyl-4-nitro-l-(p-nitro-phenyl)-2-pyrazolin-5-onate dihydrate [C12H17N4OS+, C10H7N4O3 , 2(H20)]. Shin W, Pletcher J, Blank G, Sax M (1977) J Am Chem Soc 99 3491 THYBNZ10. Thymine-p-benzoquinone complex (C3H6N202, C6H402). Sakurai T, Okunuki M (1971) Acta Crystallogr, Sect B 27 1445... 

Cyclohexan 5-(4-Fluor-phenyl)-2-methyl-4-nitro-l-oxo- E2lc, 2796 (2-NRj —t,3-dien +... 

A soln. of 4-amino-8-nitro-l-phenyl-l,3-dihydro-2H-l,5-benzodiazepin-2-one in djoxane treated with excess methyl fluorosulfonate, and stirred 45 min. 4(5H)-imino-5-methyl-8-nitro-l-phenyl-lH-l,5-benzodiazepin-2(3H)-one. Y 72-94%. -Other methods failed. F. e. s. A. Bauer et al., A. 1973, 969 methyl fluorosulfonate as methylating agent, review, s. R.W. Alder, Chem. Ind. 1973, 983. 

CH3 H H 3 l-Metkyl-4-nitro-S-phenyl-sulfonyl-... + l-Methyl-5-nitro-4-phenylsulfonyl-... (60/40) 99 64-69... 

The nitration of 27 using nitric acid in acetic anhydride at -5°C gives the 4-nitropyrazole (39%) without phenyl group substitution. This product can be nitrated further to 3-methyl-4-nitro-5-(3-nitrophenyl)-1-phenylpyrazole (7%) and 3-methyl-4-nitro-5-(3-nitrophenyl)-l-(4-nitro-phenyDpyrazole (50%) using nitric acid sulfuric acid (Fig. 7). 

The nitration (fuming nitric acid) of 5-chloro-3-methyl-l-phenylpyrazole is reported to give a mononitro product (presumably the 4-nitrophenyl derivative) and a dinitro product 5-chloro-3-methyI-4-nitro-l-(4-nitro-phenyl)-pyrazole (1900CB2595 11LA329). 

Bromination and nitration of substituted 1,2-selenazoles occurs at the 4-position but products undergo decomposition. 3-Methyl-5-phenyl-l,2-selenazole reacts with a mixture of concentrated nitric and sulfuric acids to give 3-methyl-4-nitro-5-(4-nitrophenyl)-l,2-selenazole in 54% yield, accompanied by other nitroderivatives. Bromination and nitration of 1-benzo-1,2-selenazoles results in substitution in the benzene ring and does not occur at the 3-position thus nitration afforded an almost equimolar mixture of 5-nitro- and 7-nitro-l-benzo-l,2-selenazoles in an overall quantitative yield, while bromination led to a mixture of mono-, di-, and tribromo compounds [2, 10]. 

Chemical Name l,3-Dihydro-l-methyl-7-nitro-5-phenyl-2H-l,4-benzodiazepin-2-one... 

Nitro-l-phenyl-ethen reagiert analog zu 1-Phenyl-ethenphosphonsdure-dialkylestem (60-85%)398 rra s-l,2-Bis-[4-methyl-phenylsulfonyl]-ethen liefert mit Phosphorigsaure-trimethylester trans-2-(4-Methyl-phenylsulfonyl)-ethenphosphonsaure-dimethylester (83% Schmp. 105-1080)399 ... 

Chlor-4-methyl-6-nitro-benzol- XII/1, 378 5-Chlor-3-methyl-l-phenyl-pyrazol-4- XII/1, 371... 

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