Methyl esters, reductive

Grignard reaction, 3, 711 mass spectra, 3, 615 methyl ester reduction, 3, 710 reactions... 

Hydrolysis of 20 with the aid of butanol followed by syn-selective reduction of jS-keto ester 21 and protection as the isopropylidene acetal was accomplished in 87% yield. L1A1H4 reduction and TBS protection of the primary alcohol gave 22 in very good yields. In this strategy, the furan residue serves as an aldehyde synthon and ozonolysis followed by esterification gave the corresponding methyl ester. Reduction and consecutive oxidation established aldehyde 23 in 71% yield. 

Table 4.3 Phenylglyoxylate methyl ester reduction in the presence of lr(l) and 29a-e.

Alcohols from esters. The major problem is reaction selectivity. Paraffin by-product in alcohol results if the catalyst activity is too high. Yet the reduction of esters to alcohols is a difficult reaction. Copper chromite catalyst, 3000-5000 psig hydrogen, and a temperature of 270-300°C are required for the reduction. An alternate catalyst is CuO/ZnO, which is used for methyl ester reduction only. Hydrogen solubility in alcohol is limiting. 

An analogous synthesis of acromelic acid B 6 was also attempted using enamide 185. C-2 methyl ester reduction and hydroxyl-directed enamide hydrogenation proceeded smoothly giving a 10 1 mixture of C-4 epimeric catechols, 197 and 198 (Scheme 74). 

The first commercial production of fatty alcohol ia the 1930s employed the sodium reduction process usiug a methyl ester feedstock. The process was used ia plants constmcted up to about 1950, but it was expensive, hazardous, and complex. By about 1960 most of the sodium reduction plants had been replaced by those employing the catalytic hydrogenolysis process. Catalytic hydrogenation processes were investigated as early as the 1930s by a number of workers one of these is described ia reference 26. 

Secondary alcohols (C q—for surfactant iatermediates are produced by hydrolysis of secondary alkyl borate or boroxiae esters formed when paraffin hydrocarbons are air-oxidized ia the presence of boric acid [10043-35-3] (19,20). Union Carbide Corporation operated a plant ia the United States from 1964 until 1977. A plant built by Nippon Shokubai (Japan Catalytic Chemical) ia 1972 ia Kawasaki, Japan was expanded to 30,000 t/yr capacity ia 1980 (20). The process has been operated iadustriaHy ia the USSR siace 1959 (21). Also, predominantiy primary alcohols are produced ia large volumes ia the USSR by reduction of fatty acids, or their methyl esters, from permanganate-catalyzed air oxidation of paraffin hydrocarbons (22). The paraffin oxidation is carried out ia the temperature range 150—180°C at a paraffin conversion generally below 20% to a mixture of trialkyl borate, (RO)2B, and trialkyl boroxiae, (ROBO). Unconverted paraffin is separated from the product mixture by flash distillation. After hydrolysis of residual borate esters, the boric acid is recovered for recycle and the alcohols are purified by washing and distillation (19,20). 

Catalytic hydrogenation of the 14—15 double bond from the face opposite to the C18 substituent yields (196). Compound (196) contains the natural steroid stereochemistry around the D-ring. A metal-ammonia reduction of (196) forms the most stable product (197) thermodynamically. When R is equal to methyl, this process comprises an efficient total synthesis of estradiol methyl ester. Birch reduction of the A-ring of (197) followed by acid hydrolysis of the resultant enol ether allows access into the 19-norsteroids (198) (204). 

Acetic acid, 3-ethoxycarbonyl-l-methyl-2-pyrrolyl-ethyl ester reduction, 4, 287 Acetic acid, 9-hydroxyethoxy-as metabolite of dioxane, 1, 245... 

H-Benzimidazole, 2,2-pentamethylene-reduction, 5, 423 Benzimidazole-2-carbaldehyde oximes, 5, 436 Benzimidazolecarbaldehydes oxidation, 5, 437 Benzimidazole-2-carbamates 5-substituted as anthelmintics, 1, 202 Benzimidazole-1-carboxylic acid, 2-amino-methyl ester reactions, 5, 453... 

H-Chromene, 2-ethyl-3-phenyl-synthesis, 3, 764 4H-Chromene, 2-phenyl-synthesis, 3, 763 4H-Chromene, 2,4,4-trimethyl-addition reactions, 3, 669 2 H-Chromene-3-carboxamide reduction, 3, 675 2H-Chromene-3-carboxylic acid methyl ester alcoholysis, 3, 668... 

Archer, owing to very unfortunate coincidences, had mistaken acid potassium tartrate for the acetylamino acid. Goldfarb et al. prepared authentic 5-acetylamino-2-thiophenecarboxylic acid, mp 230 232°C (methyl ester, mp 171-171.5°C ethyl ester, mp 161°C), through reduction of 5-nitro-2-thiophenecarboxylic acid with Raney nickel in acetic anhydride and proved the structure by Raney nickel desulfurization to 8-aminovaleric acid. They also confirmed that the acid mp 272-273°C (methyl ester, mp 135-136°C ethyl ester, mp 116-117°C) is 4-acetylamino-2-thiophenecar boxy lie acid as originally stated by Steinkopf and Miiller. The statement of Tirouflet and Chane that the acid obtained upon reduction and acetylation of 5-nitro-2-thiophenecarboxylic acid melts at 272°C must result from some mistake as they give the correct melting point for the methyl ester. 

The complex thioamide lolrestat (8) is an inhibitor of aldose reductase. This enzyme catalyzes the reduction of glucose to sorbitol. The enzyme is not very active, but in diabetic individuals where blood glucose levels can. spike to quite high levels in tissues where insulin is not required for glucose uptake (nerve, kidney, retina and lens) sorbitol is formed by the action of aldose reductase and contributes to diabetic complications very prominent among which are eye problems (diabetic retinopathy). Tolrestat is intended for oral administration to prevent this. One of its syntheses proceeds by conversion of 6-methoxy-5-(trifluoroniethyl)naphthalene-l-carboxyl-ic acid (6) to its acid chloride followed by carboxamide formation (7) with methyl N-methyl sarcosinate. Reaction of amide 7 with phosphorous pentasulfide produces the methyl ester thioamide which, on treatment with KOH, hydrolyzes to tolrestat (8) 2[. 

Spirapril (37) is a clinically active antihypertensive agent closely related structurally and mechanistically to enalapril. Various syntheses are reported with the synthesis of the substituted proline portion being the key to the methods. This is prepared fkim l-carbobenzyloxy-4-oxopro-line methyl ester (33) by reaction with ethanedithiol and catalytic tosic acid. The product (34) is deprotected with 20% HBr to methyl l,4-dithia-7-azospiro[4.4 nonane-8-carboxylate (35), Condensation of this with N-carbobenzyloxy-L-alanyl-N-hydroxysuccinate leads to the dipeptide ester which is deblocked to 36 by hydrolysis with NaOH and then treatment with 20% HBr. The conclusion of the synthesis of spirapril (37) follows with the standard reductive alkylation [11]. 

When perillic acid is dissolved in five times its weight of amyl alcohol and is reduced by sodium at the boiling temperature, dihydro-perillic acid, CjoH Oj, is obtained. This acid melts at 107° to 109° C. By the reduction of its methyl ester by means of sodium, dihydroperillic alcohol is fornned, which is a liquid with a rose odour and having the following characters —... 

Although the biosynthetic cascade hypothesis predicts the co-occurrence of endiandric acids D (4) and A (1) in nature, the former compound was not isolated until after its total synthesis was completed in the laboratory (see Scheme 6). Our journey to endiandric acid D (4) commences with the desilylation of key intermediate 22 to give alcohol 31 in 95% yield. The endo side chain is then converted to a methyl ester by hydrolysis of the nitrile to the corresponding acid with basic hydrogen peroxide, followed by esterification with diazomethane to afford intermediate 32 in 92% overall yield. The exo side chain is then constructed by sequential bromination, cyanide displacement, ester hydrolysis (33), reduction, and olefination (4) in a straight-... 

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