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Serotonergic hallucinogens

Sloviter, R. S., Drust, E. G., Dammiano, B. P., and Conner, J. D. (1981) A common mechanism for lysergic acid, indolealkylamine and phenethylamine hallucinogens Serotonergic mediation of behavioral effects in rats. J. Pharmacol. Exp. Ther., 214 231-238. [Pg.54]

Heym, J. Rasmussen, K. and Jacobs, B.L. Some behavioral effects of hallucinogens are mediated by a postsynaptic serotonergic action ... [Pg.299]

Further evidence for serotonergic mediation of the effects of hallucinogens was provided by a report on the development of functional supersensitivity in the rat with a chronic denervation of spinal 5-HT neurons. Nygren et al. (138) reported that rats pretreated with intracistemally administered 5,6-dihydroxy-tryptamine (5,6-DHT), a 5-HT neurotoxin, subsequently showed greater hindlimb extensor facilitations to 5-MeODMT or L-tryptophan + nialamide at 1 week versus 1 day following pretreatment. [Pg.26]

Whitaker, P. M., and Seeman, P. (1978) High-affinity 3H-serotonin binding to caudate Inhibition by hallucinogens and serotonergic drugs. Psychopharmacology, 59 1-5. [Pg.54]

In conclusion, in vitro as well as in vivo studies with 3H-LSD revefiled that specific sites which bind the labeled hallucinogen do exist in brain. These sites apparently do not correspond to receptors for hallucinogens but to specific postsynaptic receptors for 5-HT. It can be inferred that serotonergic synapses may be a preferential target for hallucinogens, at least for those of the LSD series. As discussed below, numerous biochemical investigations on brain 5-HT metabolism confirm this hypothesis. [Pg.81]

This section is a selective review of behavioral pharmacology studies in animals and humans that are consistent with a postsynaptic serotonergic action of LSD-like hallucinogens. (See also the chapters by Davis et al., Appel and Rosecrans, and Nichols and Glennon, this volume.)... [Pg.103]

Postsynaptic Serotonergic Action of Hallucinogens Barry L. Jacobs... [Pg.128]

Yamamoto, T., and Ueki, S. (1981) The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs. Pharmacol. Biochem. Behav., 14 89-95. [Pg.167]

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See also in sourсe #XX -- [ Pg.278 , Pg.279 ]



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