Methods to enhance cellular infiltration of electrospun scaffolds

4 Methods to enhance cellular infiltration of electrospun scaffolds 

Coelectrospinning is described as blending two or more polymers for electrospinning. To accelerate the degradation, some relatively quickly degradable materials are combined with the major polymer in a single solution to achieve a composite scaffold. The material introduction can increase the scaffold degradation rate, which may allow more cell infiltration, and it also can render some extra functionality to 

These above methods are feasible and effective for changing the architecture of the dense fibrous scaffolds for improved cell infiltration. However, the scaffold loosening inevitably induces a decrease of the mechanical strength of scaffolds. It can also result in the accelerated degradation of the submicrometer fibrous scaffold as the fluid and the cells can rapidly penetrate into the scaffold. Thus, one must consider these changes of material properties prior to applying a loosened scaffold for tissue engineering. 

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