Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Method development instrument/system considerations

Table 1 summarizes several of the experimental methods discussed in this chapter. A need exists for new or revised methods for transport experimentation, particularly for therapeutic proteins or peptides in polymeric systems. An important criterion for the new or revised methods includes in situ sampling using micro techniques which simultaneously sample, separate, and analyze the sample. For example, capillary zone electrophoresis provides a micro technique with high separation resolution and the potential to measure the mobilities and diffusion coefficients of the diffusant in the presence of a polymer. Combining the separation and analytical components adds considerable power and versatility to the method. In addition, up-to-date separation instrumentation is computer-driven, so that methods development is optimized, data are acquired according to a predetermined program, and data analysis is facilitated. [Pg.122]

Type of Service. The type of service—quality assurance, methods development, or routine testing—for each instrument or laboratory is a general consideration, as is the question of whether several types of service will be required of the system. A quality assurance laboratory associated with a chemicals production facility has far simpler needs in terms of analytical capability than a methods development laboratory or one that normally analyzes biological samples for pharmacologically active compounds at sub-ppm or even ppb concentrations. On the other hand, the data storage and reduction needs of a quality assurance laboratory are usually much more pressing than those of a methods development laboratory. [Pg.430]

The ultimate in selectivity in HPLC detection is seen with the use of mass-spectrometric detection, and for many applications this could be seen as the ideal detection method. However, more mundane considerations such as size of the instrumentation and limited budgets combine to reduce HPLC-MS to a relatively small number of applications which most effectively exploit its unique properties. When such practical constraints are taken into account, the real detector coimected to the HPLC system usually turns out to be a device that is a compromise, and its performance characteristics need to be taken into account during the development of many analyses just as much as the performance of the column or any other component of the HPLC system. For example, lack of detection selectivity may require extra method development to completely resolve an interfering peak, or lack of sensitivity could force the inclusion of an extraction-concentration step in an analytical method to achieve detectable levels of analyte. [Pg.115]


See other pages where Method development instrument/system considerations is mentioned: [Pg.760]    [Pg.194]    [Pg.304]    [Pg.421]    [Pg.324]    [Pg.438]    [Pg.429]    [Pg.8]    [Pg.24]    [Pg.284]    [Pg.392]    [Pg.393]    [Pg.1027]    [Pg.753]    [Pg.155]    [Pg.733]    [Pg.226]    [Pg.318]    [Pg.729]    [Pg.7]    [Pg.248]    [Pg.327]    [Pg.190]    [Pg.200]    [Pg.588]    [Pg.616]    [Pg.140]    [Pg.131]    [Pg.20]    [Pg.66]    [Pg.1]    [Pg.349]    [Pg.309]    [Pg.200]    [Pg.588]    [Pg.2206]    [Pg.211]    [Pg.626]    [Pg.181]    [Pg.24]    [Pg.30]    [Pg.286]    [Pg.244]    [Pg.115]    [Pg.124]    [Pg.300]    [Pg.194]    [Pg.2124]   
See also in sourсe #XX -- [ Pg.438 , Pg.442 ]




SEARCH



Instrument development

Instrumental considerations

Instrumental development

Instrumental methods

Instrumentation Considerations

Instrumentation, developments

Method development

Method development considerations

System Development

System method

Systemic considerations

Systems Considerations

Systems developed

© 2024 chempedia.info