Metastasis of tumors

A1. Alvarez, O. A., Carmichael, D. F., and DeClerck, Y. A., Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases. J. Natl. Cancer Inst. 82, 589-595 (1990). 

Naito, S., von Eschenbach, A. C., Giavazzi, R. and Fidler, 1. J. (1986). Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res. 46, 4109-4115. 

Lee CM et al (2002) Novel chondroitin sulfate-binding cationic liposomes loaded with cisplatin efficiently suppress the local growth and liver metastasis of tumor cells in vivo. Cancer Res 62 4282 288... 

Proteinases and their inhibitors play a major role in metastasis of cancer. Metastasis of tumors requires remodeling of extracellular matrix (ECM). Remodeling is a balance between proteolysis and respective proteinase inhibitors. This process is aided by proteolytic enzymes... 

Taking these factors into consideration, the intravenous administration of Hpoplex may represent a promising gene dehvery method to treat pulmonary diseases. Simple gene delivery can be an effective approach for the treatment of lung diseases, including pulmonary metastasis of tumor cells. Indeed, the intravenous administration of interferon (IFN)-/9- and interleukin (IL)-12-encoding pDNA has been shown to provide effective treatment in a murine pulmonary cancer metastasis model [27, 28]. 

Folkman J, Long DM, Becker FF. Growth and metastasis of tumor in organ culture. Cancer 1963 16 453 67. 

The heterogeneity of tumor cells and tumor physiology, metastasis of tumor, and cancer stem-like cells restricts research on polymeric carriers. These hurdles still remain as challenges for the development of multifunctional and custom-made polymeric carriers. Nonetheless, the combined findings from polymer chemistry and tumor biology provide researchers with the potential tools to overcome such barriers in the future. 

Suppressive effect of lentinan on spontaneous pulmonary metastasis of tumors. 

Scheme 2 General scheme of metastasis of tumor cells.

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