Metallothionein induction

Benson, W.H. and W.J. Birge. 1985. Heavy metal tolerance and metallothionein induction in fathead minnows results from field and laboratory investigations. Environ. Toxicol. Chem. 4 209-217. 

Hogstrand, C., F. Galvez, and C.M. Wood. 1996. Toxicity, silver accumulation and metallothionein induction in freshwater rainbow trout during exposure to different silver salts. Environ. Toxicol. Chem. 15 1102-1108. 

Daston GP, Overmann GJ, Taubeneck MW et al (1991) The role of metallothionein induction and altered zinc status in maternally-mediated developmental toxicity. Comparison of the effects of urethane and styrene in rats. Toxicol Appl Pharmacol 110 450-463... 

Ghoshal K, Wang Y, Sheridan JF, Jacob ST (1998) Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J Biol Chem 273 27904-27910... 

Geffard, A., C. Amiard-Triquet, and J.-C. Amiard. 2005. Do seasonal changes affect metallothionein induction by metals in mussels, Mytilus edulisl Ecotoxicol. Environ. Saf. 61 209-220. 

Kling, P, L.J. Erkell, P. Kille, and P.E. Olsson. 1996. Metallothionein induction in rainbow trout gonadal (RTG-2) cells during free radical exposure. Mar. Environ. Res. 42 33-36. 

In Chinese Cd-exposed workers it was demonstrated that those with a high ability to induce metallothionein suffered less tubular damage than those with a low ability to induce metallothionein in peripheral blood lymphocytes [159]. Similar observations were reported from a population group in China environmentally exposed to cadmium [160]. These observations give support for an important role of metallothionein induction in humans and that such induction in peripheral blood lymphocytes can be used as a biomarker of individual sensitivity to development of renal damage. 

Coyle P, Philcox JC, Rofe AM. Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor. Inflamm Res 1996 44 475-81. 

Cosson, R.P. Heavy metal intracellular balance and relationship with metallothionein induction in the gills of carp. After contamination by Ag, Cd, and Hg following pretreatment with Zn or not. Biol. Trace Elem. Res. 46 229-245, 1994. 

George, S., D. Burgess, M. Leaver and N. Frerichs. Metallothionein induction in cultured fibroblasts and liver of a marine flatfish, the turbot, Scophthalmus maximus. Fish Physiol. Biochem. 10 43-54, 1992. 

Iwai N, Watanabe C, Suzuki T, et al. 1988. Metallothionein induction by sodium selenite at two different ambient temperatures in mice. Arch Toxicol 62(6) 447-451. 

Bebianno MJ, Iangston WJ and Simkiss K (1992) Metallothionein induction in Littorina littorea (Mollusca Prosobranchia) on exposure to cadmium. J Mar Biol Ass UK 72 329-342. 

Sanchez-Reus mi, Iniesta MP and Ribas B (1988) Metallothionein induction by methotrexate in liver and intestinal mucosa. In Schramel P and Bratter P, eds. Trace Elements in Analytical Chemistry and Medicinal Biology, Vol. 5, pp. 437-443. Walter de Gruyter Co., Berlin-New York... 

Cadmium is 10 times more efficient than zinc in metallothionein induction in vitro (Harford and Sarkar 1991). Induction by either cadmium or zinc alone is saturable however, simultaneous... 

Hepatic zinc levels are elevated in patients with hemochromatosis, a genetic disease associated with increased iron absorption from the intestine (Adams et al. 1991). The chronic iron loading that occurs could result in hepatic metallothionein induction leading to the accumulation of zinc because metallothionein has a greater affinity for zinc than iron. These individuals may, therefore, have a greater likelihood of developing toxicity with zinc exposure levels that do not normally result in any symptoms in the general population. 

Steffensen IL, Mesna OJ, MeIhuusA, etal. 1991. Mitogenicity and metallothionein induction Two separate effects of zinc ions on human mononuclear blood cells. Pharmacol Toxicol 68(6) 445- 449. 

Xuan A, Bookman I, Cox DW, Heathcote J. Three atypical cases of Wilson disease Assessment of the Leipzig scoring system in making a diagnosis. J Hepatol. 2007 47 428-433 Yuzbasiyan-Gurkan V, Grider A, Nostrant T, Cousins RJ, Brewer GJ. Treatment of Wilson s disease with zinc X. Intestinal metallothionein induction. J Lab Chn Med 1992 120 380-386... 

Koropatnick J, Leibbrandt M, Cherian MG (1989) Organ-specific metallothionein induction in mice by x-irradiation. Radiat Res 119 356-365 Lehman-McKeeman LD, Kershaw WC, Klaassen CD (1991) Species differences in metallothionein regulation a comparison of the induction of isometallothioneins in rats and mice. In Klaassen CD, Suzuki KT (eds) Metallothionein in biology and medicine, CRC, Boca Raton, pp 121-132 Lui EMK (1987) Metabolism of copper and zinc in the liver and bone of perinatal guinea pig. Comp Biochem Physiol 86 173-183 Maitani T, Cuppage FE, Klaassen CD (1988) Nephrotoxicity of intravenously injected cadmium-metallothionein critical concentration and tolerance. Fund Appl Toxicol 10 98-108... 

Matsubara J, Tajima Y, Karasawa M (1987) Promotion of radioresistance by metallothionein induction prior to irradiation. Environ Res 43 66-74 Miller L, Qureshi MA (1992) Heat-shock protein synthesis in chicken macrophages influence of in vivo and in vitro heat shock, lead acetate, and lipopolysaccharide. Poult Sci 71 988-998... 

Nartey N, Cherian MG, Banerjee D (1987) Immunohistochemical localization of metallothionein in human thyroid tumors. Am J Pathol 129 177-182 Pattanaik A, Bachowski G, Laib J, Lemkuil D, Shaw CF III, Petering DH, Hitchcock A, Saryan L (1992) Properties of the reaction of cis-dichlorodiammine-platinum(II) with metallothionein. J Biol Chem 267 16121-16128 Satoh M, Naganuma A, Imura N (1988) Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination. Cancer Chemother Pharmacol 21 176-178... 

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