Metabolism variability

The reported intake of dairy foods has been identified in both observational and experimental studies to be associated with improvements in several metabolic variables (Bowen et al., 2005). Specific metabolic... 

Beyond phase I (oxidative) and phase II (conjugative) statin metabolism, variability in membrane transport also contributes strongly to myopathy risk. The organic anion transporting... 

Citrome L, Holt BI, Walker DJ, Hoffmann VP (2011) Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder. Clin Drug Investig 31 455 182... 

Liver metabolism to form active metabolites (see Table IV-1-1 and sidebar), but no induction of drug metabolism—variable half-life. 

Francko, D.A. (1982) The isolation of cyclic 3, 5 -monophosphate (cAMP) from lakes of differing trophic status correlation with planktonic metabolic variables. Limnology and Oceanography 27, 27-38. 

The principal advantage of measuring BV relative to another protein diet is accuracy it helps account for some of the metabolic variability between individuals. In a simplistic sense the egg diet is testing the maximum efhciency of the individual to take up protein, the BV is then provided as a percentage taking this as the maximum. 

Bioavailability As for absorption As for absorption and metabolism Variable. Influenced by metabolism... 

The concept of balanced growth was introduced by Campbell (1957) to describe a metabolic state of a culture in terms of the distributed concentration (xj) or total mass (X- ) of a metabolic variable. According to Campbell s definition, growth is balanced when the specific rate of change of all such variables is constant. That is. 

Several important concepts are illustrated by these observations. First, it is essential that a range of metabolic variables be considered before any well-based decision can be made as to whether balanced growth has been achieved. In addition, and most important, some metabolic processes achieve a balanced growth condition more rapidly than others (e.g., and RQ before and qc). Consequently, the variable that is used as the criterion for the attainment of balanced growth must be carefully chosen and explicitly stated. 

It is possible to consider steady-state growth as an extension of balanced growth. That is, in addition to the definitions outlined previously, a further requirement is that the overall time rate of change of the distributed concentration (xj) or total mass (Xj) of any metabolic variable be zero. That is. 

The benefits of using TDDS include the improvement of systemic bioavait-ability, as a result of bypassing the first pass metabolism. Variables due to oral administration, such as pH, the presence of food or enzymes and transit times can all be eliminated. TDDSs also allow for fast interruption of the treatment in the case of any adverse effects. Textile materials are often permeable, comfortable, aesthetic, breathable structures, which are also easy to use, and can usually be treated to improve their absorptive capacity. 

Filppula AM, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT (2013) Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism variability in CYP2C8 activity may alter plasma concentrations and response. Drug Metab Dispos 41 50 59... 

As shown previously (Vorobjeva and Iordan, 1976), the content of 2 pg vitamin Bn per g of dry biomass of P. shermanii represents a threshold for the isomerization to proceed. In these studies, a number of metabolic variables were investigated in vitamin Bn-replete cells (about 1000 pg vitamin B /g biomass), Bn-deficient cells (about 10 pg vitamin B /g biomass) and Bn-depleted cells (at most 2 pg vitamin Bn/g biomass). The cellular vitamin Bn content was varied by changing the concentration of a cobalt salt in the growth medium, or by using a mutant strain that produced only traces of corrinoids. 

Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population. 

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