Proton pump inhibitors Fluvoxamine

FLUVOXAMINE PROTON PUMP INHIBITORS -OMEPRAZOLE 1 fluvoxamine levels with loss of therapeutic efficacy Inhibition of CYP1 A2-mediated metabolism Monitor for lack of therapeutic effect. When omeprazole is withdrawn, monitor for fluvoxamine toxicity... 

Fluvoxamine markedly inhibits the metabolisim of the proton pump inhibitors lansoprazole, omeprazole and rabeprazole in those of the CYP2C19 extensive metaboliser phenotype, producing levels comparable to those in poor metabolisers. However, these increases are probably of little clinical relevance. Theoretically escitalopram may have the same effect. Omeprazole may increase escitalopram levels. 

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