Metabolic engineering of lactic acid bacteria

Hugenholtz, J., and Kleerebezem, M. 1999. Metabolic engineering of lactic acid bacteria overview of the approaches and results of pathway rerouting involved in food fermentations. Curr. Op. Biotechnol., 10,492-497. 

Hoefnagel, M.H.N., Starrenburg, M.J.C., Martens, D.E., Hugenholtz, J., Kleerebezem, M., Van Swam, I.I., Bongers, R., Westerhoff, H.V. and Snoep, J.L. (2002) Metabolic engineering of lactic acid bacteria, the combined approach kinetic modelling, metabolic control and experimental analysis. Microbiology 148,1003-1013. 

Lactic acid bacteria are used to produce fermented milk products, and the exopolysaccharides produced by the bacteria influence the texture of the resulting products. More importantly, these exopolysaccharides are thought to have several health benefits. There is evidence they lower cholesterol, modulate the immune system, help prevent colon cancer, and fight ulcers [342,343]. There is thus interest in establishing stmcture-function relationships for these stmctures, as well as in metabolic engineering of lactic acid bacteria to produce capsular polysaccharides with the desired properties [342,343]. 

Papagianni, M (2012) Metabolic engineering of lactic acid bacteria for the production of industrially important compounds. Comput Struct. Biotechnol )., 3, 1-8,... 

Systems biology and metabolic engineering of lactic acid bacteria for improved fermented foods... 

Kleerebezemab, M., Hols, P., and Hugenholtz, J. 2000. Lactic acid bacteria as a cell factory rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering. Enz. Microbial Technol., 26, 840-848. 

Caspar, R, Carvalho, A. L., Vinga, S., Santos, H., Neves, A. R. (November 2013). From physiology to systems metabolic engineering for the production of biochemicals by lactic acid bacteria. Biotechnology Advances, 31(6), 764—788. 

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