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Modified cell lines

Caco-2 Human colon adenocarcinoma cell line used as absorption model cDNA Complementary DNA [Pg.329]

MDR1 Multidrug resistance protein 1 (also designated P-gp and ABCB1). [Pg.329]

MRP2 Multidrug resistance-associated protein 2 (also designated ABCC2). [Pg.329]

A clear priority remains to expand the panel of intestinal efflux transporters that are expressed individually in modified cell lines. These research tools will be instrumental in identifying and validating selective probe transporter substrates and inhibitors. The availability of such probes will allow for a better understanding of the influence of transporters on in vivo pharmacokinetics. A similar set of probes has been instrumental in increasing our understanding of the role that cytochrome P450 plays in human pharmacokinetics and in avoiding issues associated with these enzymes. [Pg.335]

Schwarzenberger P, Lei D, Freeman S, et al. Antitumor activity with the HSV-tk-gene-modified cell line PA-1 -STK in malignant mesothelioma. Am J Respir Cell Mol Biol 1998 19 333-337. [Pg.272]

See other pages where Modified cell lines is mentioned: [Pg.329]    [Pg.330]    [Pg.332]    [Pg.334]    [Pg.336]    [Pg.338]    [Pg.8]    [Pg.99]    [Pg.57]    [Pg.171]    [Pg.20]    [Pg.359]    [Pg.360]    [Pg.362]    [Pg.364]    [Pg.366]    [Pg.366]    [Pg.368]    [Pg.370]    [Pg.372]    [Pg.129]    [Pg.183]   
See also in sourсe #XX -- [ Pg.329 ]



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Modified cells

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