Alcohols opening

Alcohol Open cup Closed cup Lower Upper Auto ignition temperature, °C... 

Fig. 9 Diagram of the band origin shifts Ai of the molecular complexes between ( )-(+)-l-pheny 1-1-propanol (C ) and primary and secondary alcohols and amines. The circles refer to primary alcohols (open circles = full circles = the diamonds refer to secondary alcohols and amines (open diamonds = Av, full diamonds = Av/ ).

Sodium in alcohol opens one thiophene ring of thienothiophene (2) to give 2-ethyl-3-mercaptothiophene (227), which was characterized as its mercury derivative (228) [Eq. (74)]. 

Interestingly, solution studies on the namre of the active catalyst, carried out in the case of Ti(IV)-tartrate catalysts proposed by Katsuki and Sharpless for the enantioselective oxidation of allylic alcohols, opened routes to enantioselective oxidations of thioethers . ... 

Alcohols (open chained or cyclic including X- and R-Derivates without Steroids and Sugars) ... 

As already mentioned (Section III,D), reduction with sodium potassium alloy at —100° of thieno[3,2-6]thiophene (2) generates a short-lived radical-anion on the alloy surface.1 7,188,237 Sodium in alcohol opens one thiophene ring of thienothiophene (2) to give 2-ethyl-3-mercaptothiophene (227), which was characterized as its mercury derivative (228)18 [Eq. (74)]. 

The mild reaction conditions (relatively weak amine bases, short reaction times) of the CIR of (hetero)aryl halides and l-(hetero)aryl propargyl alcohols opens a modular entry to chalcones, which are as Michael acceptors suitable starting points for consecutive multicomponent syntheses of heterocycles in a one-pot fashion [28, 86]. Both catalytic generations of ynones and enones have set stages for diversity-oriented multicomponent syntheses of heterocycles in a consecutive one-pot fashion. 

Booker-Milburn et al. used the oxidative ring-expansion/cycHzation strategy they previously developed as an efficient way to stereoselectively build the bicyclo [5.3.0] framework of terpene-based natural products. For example, reaction of substrate 258 with iron (in) nitrate in DMF led to the formation of keto-alcohol 260 in fair yield as a single diastereomer (Scheme 76) [214]. Reduction of the final radical coming from the cyclization of 259 by 1,4-cyclohexadiene was smooth and the overall reaction proceeded without protection of the tertiary alcohol, opening the way to the total synthesis of pogostol and kessane. 

If you leave a bottle of wine (which contains alcohol) opened and exposed to the air, it will, after a while, start to smell (and taste) of sour apples. Leave it a little while longer and it will start to smell (and taste) of vinegar. This is because the wine contains ethanol (a primary alcohol) which reacts with and is oxidised by the oxygen in the air (shown as [O]) in the presence of micro-organisms such as Mycoderma aceti, as shown in Figure 7.1.7. 

In the following example, the morphology, at the molecular level, will play a special role. Using diols, instead of n alcohols opens the possibility of having these molecules tight on the surface by their both terminal hydroxyl groups ... 

It is apparent that the Lewis-acid solvents (alcohols, carboxylic acids, and chlorinated hydrocarbons) provide much better selectivity for a given capacity than do the Lewis-base solvents (ketones, esters, amines, phosphoryls). Furthermore, branching of the solvent molecule is important, as shown In Fig. 15.2-7. The dashed lines relate selectivity so KD for normal carboxylic acids (solid points) and normal alcohols (open points). Branched carboxylic acids give substantially higher selectivities than do straight-chain acids for a given value of K0. The same is liue for alcohols. 

P-Azido alcohols. Opening of epo is catalyzed by BU4NF under solvent-free cc... 

Lithium 2-(pyrrolidin-l-ylmethyl)pyrr Chiral allylic alcohols. Opening nishes products with moderate enantiome... 

Chiral allylic alcohols. Opening of meso-epoxides by the chiral base furnishes products with moderate enantiomer excess. 

Can either of these processes be adapted to the present question Sorbyl alcohol is an allylic alcohol, and we have just seen (Section 14-3) that allylic halides readily undergo both Sn2 and S l displacement reactions. A good deal of Chapter 9 dealt with comparing and contrasting the behavior of haloalkanes with that of alcohols Protonation of the OH group of an alcohol opens the way to both substitution and elimination chemistry. We should therefore expect that allylic alcohols will be similarly reactive. We need next to consider whether the Sn2 or the SnI mechanism is more appropriate. 

Replacing the first amine with ahphatic or aromatic alcohols opens access to labeled carbamates, as illustrated with the synthesis of [ " C]mitomycin C (61) and... 

Bicyclic secondary alcohols open to cycloalkenyl cations. For example, fenchol (VIII) produces l-isopropyl-3-methylcyclohexenyl cation (IX) in over 90% yield, and the same cation forms from borneol and camphene, but in lower yield (Deno and Houser, 1963). 

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