Primaquine Mepacrine

Y = primaquine, mepacrine, amodiaquine, lepidine, plasmoquine, pentaquine, and isopentaquine, have been reported.420 Similar studies of 27 complexes of general formula [IrY3], where... 

PRIMAQUINE MEPACRINE t primaquine levels Inhibition of metabolism Warn patients to report the early features of primaquine toxicity (e.g. gastrointestinal disturbance). Monitor FBC closely... 

In rat-foot oedema tests, chloroquine sulphate in intraperitoneal doses of 10 mg/kg twice daily two days before and immediately prior to a formalin injection was found to be ineffective , whereas other workers have found chloroquine inhibitory in oral doses of 50 mg/kg . In these latter tests mepacrine, proguanil and primaquine, in oral doses of 50 mg/kg, were also effective. Chloroquine sulphate in doses of 10 mg/kg twice daily intraperitoneally for short or long term administration does not affect the development of generalized oedema produced by intraperitoneal dextran or egg-white . When administered chronically it reduces skin inflammation produced locally by chloroform, but is less effective than salicylates . ... 

Theoretically, mepacrine would be expected to elevate the serum levels of primaquine, because it increased levels of a formerly used drug pamaquine, but there do not seem to be any reports confirming or disproving this. 

Patients given pamaquine (a formerly used antimalarial that was a predecessor of primaquine, and almost identical in structure), had grossly elevated pamaquine serum levels when they were also given mepacrine. The reason is unknown. On theoretical grounds primaquine might be expected to interact with mepacrine similarly, but there seem to be no reports confirming that a clinically important interaction actually takes place. 

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