4- Mepacrine

As a practical result there are now at least six synthetic anti-malarial drugs available to malariologists, including the three pre-war drugs, pamaquln, mepacrine and plasmocide. 

As described in section 4.1, the DNA double helix must unwind to allow access ofthe polymerase enzymes to produce two new strands ofDNA. This is facilitated by DNA gyrase, the target of the quinolones. Some agents interfere with the unwinding of the chromosome by physical obstruction. These include the acridine dyes, of which the topical antiseptic proflavine is the most familiar, and the antimalarial acridine, mepacrine. They prevent strand separation by insertion (intercalation) between base pairs from each strand, but exhibit very poor selective toxicity. 

Y = primaquine, mepacrine, amodiaquine, lepidine, plasmoquine, pentaquine, and isopentaquine, have been reported.420 Similar studies of 27 complexes of general formula [IrY3], where... 

Initially approved in the 1930s as antimalarial drug, quinacrine (2) became one of the first potential substitutes to quinine. The total synthesis of quinacrine would be achieved in 1931 by German scientists at Bayer,and it would be subsequently marketed as Mepacrine or Atebrine. However, quinacrine would soon be replaced by another synthetic and more efficient antimalarial drug, chloroquine (3). 

Quinacrine is a derivative of acridine that is chemically and clinically very similar to 4-aminoqninolines. It was the primary drng for prevention and therapy of malaria dnring World War II. Today it is rarely nsed for treating malaria, althongh it is used to treat amebiasis. Synonyms of this drng are mepacrine, atabrine, acrisnxin, and others. 

Mepacrine hydrochloride (Quinacrine and its salts) in any dosage form for female sterilization or contraception. 

Intercalation has been demonstrated with a number of other compounds having a polycyclic aromatic system and groups capable of forming hydrogen bonds. Among such compounds are the antibacterial 9-aminoacridine, the antimalarials mepacrine and chloroquine, the veterinary trypanocide ethidium (246), the thioxanthone lucanthone (247 R = Me) and its more active metabolite hycanthone (247 R = CH20H), which are used in the treatment of schistosomiasis, and the antineoplastic alkaloid ellipticine (248). A number of antibiotics, including the actinomycins, echinomycin and bleomycin, also intercalate. 

C.,H22N2 140-80-7) see Chloroquinc Mepacrine 7(7J)-amino-3-[f(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-l,2,4-triazin-3-yl)thio]mcthyl]-3-ccphem-4-carboxyllc acid (Ci2H 2N505S2 58909-56-1) see Ceftriaxone (l.S - rans)-l-amino-2,3-dihydro-l//-inden-2-ol (C,jH NO 163061-74-3) see Indinavir sulfate... 

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