Membrane physical properties

Gruszecki, W.I. and K. Strzalka. 2005. Carotenoids as modulators of lipid membrane physical properties. Biochim. Biophys. Acta 1740 108-115. 

Prades, J, Vogler, O, Alemany, R, Gomez-florit, M. Funari, S.S Ruiz-Gutierrez, V. Barcelo, F. ((2011). Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties Biochimica et Biophysica Acta (BBA)- Biomenbranes., 1808... 

In summary, current evidence supports the interaction of flavonoids with membrane lipids. The associated perturbations in membrane physical properties can have a significant impact on membrane-associated processes. 

A different mechanism should account for the antioxidant ability of hydrophobic flavonoids, which can be incorporated into the bilayer where they can affect certain membrane physical properties. It is well-known that alterations in membrane rheology will affect the extension and rate of lipid oxidation. For example, increased lipid oxidation rates have been observed... 

Williams, E.E. (1998). Membrane lipids What membrane physical properties are conserved during physiochemically induced membrane restructuring Amer. Zool. 38 280-290. 

Colell, A., Garcia-Ruiz, C., Morales, A., Ballesta, A., Ookhtens, M., Rodes, J., Kaplowitz, N., Fernandez-Checa, J.C. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology 1997 26 699 - 708... 

Meddings, J. B., DeSouza, D., Goel, M., and Thiesen, S. (1990). Glucose transport and microvUlus membrane physical properties along the crypt-villus axis of the rabbit. /. Clin. Invest. 85,1099-1107. 

Several psychological disorders are currently being discussed in terms of the effect of the physical state of the membrane lipids on neurotransmitter receptor function. Hibbeln and Salem (1995) suggest that serotonin levels and membrane 22 6n-3 content are directly linked, whereby low 22 6n-3 yields low serotonin. This results in an individual being susceptible to depression or other affective diseases. These authors suggest that the depletion of 22 6n-3 induces a change in membrane physical properties, which, in turn, influences the function of either serotonergic receptors or serotonin reuptake systems. 

The importance of investigating how cholesterol content and acyl chain composition alter the physical properties of membranes is highlighted by the functional deficits associated with 22 6n-3-deficient diets and the antisocial behavior associated with varied cholesterol levels. In the context of psychological disease and neurotransmitter receptor function, it is important to investigate how compositionally induced changes in membrane physical properties influence membrane-associated signaling processes. 

McCallum CD, Epand RM. Insulin receptor autophosphorylation and signaling is altered by modulation of membrane physical properties. Biochemistry 1995 34 1815-1824. 

Although biologic membranes serve as physical barriers, it is important to recognize that their molecular constituents are in a constant state of motional flux. Many different types of molecular motion are present in biological membranes including rotation, translation and libration, each of which contributes in important ways to the physical properties of cellular membranes. Since alterations in membrane physical properties have profound effects on the kinetics of many transmembrane enzymes and modulate the rates and types of interactions between proteins, it comes as no surprise that the molecular dynamics of a cell membrane is an important modulator of signal transduction (e.g., Lenaz, 1987). Thus, biological... 

Recently, catalytic hydrogenation methods have been used to establish a connection between membrane physical properties and expression of desaturase genes in blue-green algae [40]. 

Exocytosis is a complex process that involves protein-protein and protein-hpid interactions, membrane fusion, and release of neurotransmitter. A model system that mimics this process in a protein free fashion is advantageous to study the role of the lipid bilayer in exocytosis. A totally hpidic system is useful to study the effects of altered membrane physical properties, typically accomplished by altering the components that form the membrane. Thus an artificial ceU composed of two liposomes with a lipid membrane nanotube connection and one inside the other (Figure 17.1.5) was developed (79). 

Imdakem, A. O., and Matsuura, T. (2005). Simulation of heat and mass transfer in direct contact membrane distillation (MD) The effect of membrane physical properties. J. Membr. Sci. 262, 117. 

Dietary supplements of polyunsaturated eu-3 fatty acids induce changes in membrane-associated cell functions and membrane physical properties such as fluidity [56, 58, 114]. Eicosapentaenoic acid strongly decreases blood viscosity relative to alterations of the phospholipid content in red blood cell membranes [19,128]. Furthermore, an oihancing effect of co-3 fatty acids on plasma fibrinolysis has been reported [10 Table 7]. 

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