Cholesterol-rich membranes

Wahrle, S., Das, P., Nyborg, A.C., et al. (2002) Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis., 9, 11-23. 

Schrattenholz A. and Soskic V. (2006). NMDA receptors are not alone dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate signalling. Curr. Top. Medicinal Chem. 6 663-686. 

Brown, D. A. and London, E. (2000). Structure and function of sphingolipid- and cholesterol-rich membrane rafts. ]. Biol. Chem. 275(23), 17221-17224. 

Heuman, D.M. and Bajaj, R. (1994) Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology, 106 (5), 1333-1341. 

Freeman, M. R., Cinar, B., Kim, J., Mukhopadhyay, N. K., Di Vizio, D., Adam, R. M. and Solomon, K. R., Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids 72 (2007) 210-217. 

Linden, M. V., Holopainen, J. M., Laukkanen, A., Riekkola, M. L., and Wiedmer, S. K., Cholesterol-rich membrane coatings for interaction studies in capillary electrophoresis application to red blood cell lipid extracts, Electrophoresis, 27, 3988-3998, 2006. 

Two important features of cholesterol-a-synudein interactions warrant mention here. First, the CRAC and the tilted /fusogenic domains have opposite orientations in the a-helical membrane-boimd conformation of a-synuclein (Fig. 10.7). Thus a-synuclein cannot interact simultaneously with both cholesterol molecules. If both molecules are involved in the insertion of a-synuclein in cholesterol-rich membrane, the protein binds sequentially to one... 

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