Meglitinides

These medications, such as repaglinide (7) (Prandin) (Rachman and Turner, 1995), have effects similar to sulfonylureas, but with fewer side effects in developing low blood sugar. Meglitinides work quickly, and the results fade rapidly as well. 

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Prandial insulin releasers (meglitinides) Repaglinide, nateglinide Stimulate insulin secretion (rapid and short-acting < 6 h) Oral... 

Meglitinide contains a benzamide group. Meglitinide-related compounds such as nateglinide are non-sulfonylurea oral hypoglycemic drugs used in the treatment of type 2 (non-insulin dependent) diabetes mellitus. 

MDR-ABC Transporters Mechanism-based Inhibition Meglitinide-related Compounds Melanin-concentrating Hormone Melanocortins... 

Like the sulfonylureas, the meglitinides act to lower blood glucose levels by stimulating the release of insulin from the pancreas. This action is dependent on the abilily of the beta cell in the pancreas to produce some insulin. However, the action of die meglitinides is more rapid than that of the sulfonylureas and their... 

Adverse reactions associated with the administration of tiie meglitinides include upper respiratory infection, headache, rhinitis, bronchitis, headache, back pain, and hypoglycemia... 

Meglitinides—if a meal is skipped, do not take die drug. Similarly, if a meal is added, add a dose of the drug for diat meal. 

While producing the same effect as sulfonylureas, nonsulfonylurea secretagogues, also referred to as meglitinides, have a much shorter onset and duration of action. Nonsulfonylurea secretagogues also produce a pharmacologic effect by interacting with ATP-sensitive potassium channels on the (1-cells however, this binding is to a receptor adjacent to those to which sulfonylureas bind. 

Insulin Exenatide is not a substitute for insulin in insulin-requiring patients. Do not use exenatide in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. The concurrent use of exenatide with insulin, thiazolidinediones, D-phenylalanine derivatives, meglitinides, or alpha-glucosidase inhibitors has not been studied. 

Sulfonylureas, such as glipizide and glyburide, and meglitinides, such as repaglinide and nateglin-ide, stimulate insulin secretion by the beta cells. 

Chemical Class Amino acid derivative meglitinide Clinical Pharmacology ... 

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