Medication footnote

Atazanavir PI2 400 mg daily or 300 mg daily with ritonavir 100 daily. Adjust dose in hepatic insufficiency Take with food. Separate dosing from ddl or antacids by 1 h. Separate dosing from cimetidine and other acid-reducing agents by 12 h Nausea, vomiting, diarrhea, abdominal pain, headache, peripheral neuropathy, skin rash, indirect hyperbilirubinemia, prolonged PR and/or QTC interval See footnote 4 for contraindicated medications. Also avoid indinavir, irinotecan, and omeprazole. Avoid in severe hepatic insufficiency... 

Darunavir PI2 600 mg bid with ritonavir 100 mg bid Take with food Diarrhea, headache, nausea, rash, hyperlipidemia, t liver enzymes, t serum amylase Avoid in patients with sulfa allergy. See footnote 4 for contraindicated medications... 

Delavirdine NNRTI 400 mg tid Separate dosing from ddl or antacids by 1 h Rash, t liver enzymes, headache, nausea, diarrhea See footnote 4 for contraindicated medications. Also avoid concurrent fosamprenavir and rifabutin. Teratogenic in rats... 

Etravirine NNRTI 200 mg bid Take after a meal do not take on an empty stomach. Rash, nausea, diarrhea See footnote 4 for contraindicated medications. Do not administer with other NNRTIs, indinavir, atazanavir-ritonavir, fosamprenavir-ritonavir, tipranavir-ritonavir, or any unboosted PI... 

Fosamprenavir PI2 1400 mg bid or 700 mg bid with ritonavir 100 bid or 1400 mg daily with ritonavir 100-200 mg daily. Adjust dose in hepatic insufficiency Separate dosing from antacids by 2 h. Avoid concurrent high-fat meals Diarrhea, nausea, vomiting, hypertriglyceridemia, rash, headache, perioral paresthesias, t liver enzymes See footnote 4 for contraindicated medications. Do not administer with lopinavir/ritonavir or in severe hepatic insufficiency. Also avoid cimetidine, disulfiram, metronidazole, vitamin E, ritonavir oral solution, and alcohol when using the oral solution... 

Indinavir pi 2 800 mg tid or 800 mg bid with ritonavir 100 mg bid. Adjust dose in hepatic insufficiency Best on an empty stomach. Drink at least 48 oz liquid daily. Separate dosing from ddl by 1 h. Store in original container, which contains desiccant Nephrolithiasis, nausea, indirect hyperbilirubinemia, headache, asthenia, blurred vision See footnote 4 for contraindicated medications. Also avoid efavirenz... 

Maraviroc CCR5 inhibitor 300 mg bid Muscle and joint pain, diarrhea, sleep disturbance, + liver enzymes See footnote 4 for medications that must be -administered with caution. Decrease dose to 150 mg bid with CYP3A inhibitors and increase to 600 mg bid with CYP3A inducers. Avoid rifampin... 

Saquinavir PI2 Tablets and hard gel capsules 600 mg tid Take within 2 h of a full meal. Refrigeration recommended Nausea, diarrhea, rhinitis, abdominal pain, dyspepsia, rash See footnote 4 for contraindicated medications. Avoid in severe hepatic insufficiency. Use sunscreen owing to an increase in photosensitivity. Avoid concomitant garlic capsules... 

Tipranavir PI2 Must be taken with ritonavir to achieve effective levels tipranavir 500 mg bid/ritonavir 200 mg bid. Avoid use in hepatic insufficiency. Approved for pediatric usage Take with food. Separate from ddl by at least 2 h. Avoid antacids. Avoid in patients with sulfa allergy. Refrigeration required Diarrhea, nausea, vomiting, abdominal pain, rash, t liver enzymes, hypercholesterolemia, hypertriglyceridemia See footnote 4 for contraindicated medications. Avoid concurrent fosamprenavir, saquinavir. Do not administer to patients at risk for bleeding... 

The FDA has established authority over every word, footnote, picture and nuance of all promotional activities issued by or sponsored by drug companies. That includes promotion to the consumer, press materials, detailing aids, continuing medical education, seminars, materials for managed care organizations. The agency has jurisdiction over oral statements made by a company representative to a physician. 

Activated carbon is an adsorbent as described in Chapter 3, Footnote 93, and in Appendix A2. One of the first large-scale uses of activated carbon as an adsorbent was in military gas masks where complete removal of contaminants was essential. Another essential application is removal of mercury contained in emissions from coal-fired power stations, medical incinerators, and in produced natural gas at wellheads. A value provided in cleaning operations by activated carbon adsorbent is that multiple solvent components can be captured within the same apparatus... 

Thomas Andrews (Belfast 19 December 1813-26 November 1885) studied in the Academical Institution, Belfast, then under Thomson in Glasgow, in Paris (1830) under Dumas, then medicine in Dublin and Edinburgh (M.D. 1835) professor of chemistry in the Medical College of the Academical Institution, Belfast (closed in 1849), visited Paris with Graham, F.R.S. 1849, then professor of chemistry and Vice-President of Queen s College, Belfast (1849-79). He is best known for his researches on critical phenomena, but carried out some accurate experiments on heats of neutralisation, heats of formation of metallic halides, heats of reaction of salt solutions, heats of formation of oxides and chlorides, and of water, and latent heats of evaporation. He mentions Hess in a footnote in his first paper in a later paper he says Hess s law is correct, but it is almost self-evident and scarcely required so elaborate a proof . 

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