Mechanistic study on nanomaterial-mediated tissue and cell responses

3 Mechanistic study on nanomaterial-mediated tissue and cell responses 

Based on these preliminary results, important questions on how filopodia interact with stiff topography and how the deformation of a filopodium occurs near the surface features have raised. To answer these questions, computational and modeling approaches become more powerful and effective in providing better visualization 

The studies summarized in the previous chapters clearly support the idea that nanomaterial plays a crucial role in mediating cell responses/functions (including adhesion, spreading, proliferation, differentiation, and migration). However, the underlying mechanisms as well as what exactly happen at the cell-material interface are still not well understood to date. Undoubtedly, these questions are critical for the rational and effective design and fabrication of biomaterials for orthopedics in the future. Herein, several possible answers that have been proposed and studied are introduced. 

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