Mechanisms of Mutations

Feig, D.I. and Loeb, L.A. (1993). Mechanisms of mutation by oxidative DNA damage reduced fidelity of mammalian DNA polymerase jS. Biochemistry 32, 4466—4473. 

Mutagen specificity meant something different to plant breeders than it did to geneticists working on the mechanisms of mutation. For plant breeders, the central problem was phenotypic specificity, where the outcome was a phenotypic characteristic such as disease resistance or straw stiffness (in the case of barley). Here, the ends outweighed the means in economic importance. More fundamental locus specificity and the origins of mutational outcomes were less important to breeders (Auerbach 1976 453-454). 

E. Freese2-3 (president, ex officio) 44 National Institute of Neurological Diseases and Stroke Chief, Lab. of Molecular Biology Biology Molecular mechanisms of mutation... 

J. W. Drake2 38 U. Illinois U-C, Microbiology Dept. Professor Genetics, Virology Replication and genetics of bacterial viruses molecular mechanisms of mutation... 

The evolution of MRSA strains is not fully understood, but the same mechanisms of mutation and gene transfer that exist in other species provide a likely reason. The emergence of gentamicin resistance plasmids illustrates the evolutionary potential of translocatable elements [186], MRSA strains which are also resistant to this aminoglycoside antibiotic are referred to as MGRSA. This evolutionary progression is also responsible for the formation of the -lactamase-heavy metal resistant plasmids [250]. Some MRSA isolates are penicillin-resistant by virtue of the enzyme /J-lactamase, which pre-dates the use of /8-lactams [251], However, the spread of the phenotype has probably arisen as a result of selection caused by the widespread usage of methicillin in hospitals. 

Kg. 1 Mechanism of mutation in a DNA double helix, (a) Regular recognition, (b)... 

Let us continue to discuss the mechanisms of mutations that commonly afflict the gene for p53. Within a few paragraphs we will leam some of the most likely mechanisms that account for lower rates of cancer with diets high in fruits and vegetables-... 

This apparent paradox is resolved by the mechanisms of mutation and recombination that provide for a small but essential amount of genetic change to occur in each... 

Molecular mechanisms of mutations induced by DNA lesions 00YZ1159. 

Many of the results in the first three of these categories have been obtained from experiments conducted with isolated (purified) DNA. These do not in all cases represent the situation in the living cell, and in particular the mechanism of mutation induction as a consequence of these reactions occur-... 

Takeshita, M., and Eisenberg, W. (1994). Mechanism of mutation on DNA templates containing synthetic abasic sites study with a double strand vector. Nucleic Acids Res. 22, 1897-1902. 

Moutschen-Dahmen, J., and Degraeve, N. (1966), in "Mechanism of Mutation and Inducing Factors" (Z. Landa, ed.) p. 367, Academia Publ. House, Prague. 

Rapoport, J. A. (1946). Ketonic connections and chemical mechanisms of mutations/ Doklaly Academy of Sciences USSR (Press), 54(1), 65-68. 

Freese, E., 1971, Molecular mechanisms of mutation, i "Chemical Mutagens Principles and Methods for Their Detection", A. Hollaender, ed.. Plenum Publ. Corp., New York. 

The study of bacterial viruses has provided many of the most important breakthroughs in modern biology. Thus, the role of nucleic acids in heredity and the basic mechanisms of mutation, replication, transcription and translation of the genetic material were mainly revealed through the use of bacteriophages. 

Y. Tazima and K. Onimaru, Mechanism of mutation induction by mitomycin C in the silkworm, Annu. Rep. Natl. Inst. Genet. Misima 17, 94-95 (1966). 

If he is convinced that the matter is important enough to merit serious personal involvement on his part, with the directly relevant work of assessing the impact of mutations on man and looking for possible changes in the mutation rate, he will be led far from the basic research on the mechanisms of mutation in which he was first interested. If, however, he leaves the task to others, there is a reasonable likelihood that it may not get tackled at all. Social concern in such matters has a tendency to arise first among basic scientists as an outcome of their own research, and it is often not shared in full measure by their more applied colleagues. 

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