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MC receptor

Proteochemometric Modeling of Chimeric MC Receptors Interacting with MSH Peptides... [Pg.295]

It is now well established that the MCI receptor mainly expressed in melanocytes and leukocytes plays a key role in skin pigmentation and inflammatory response (136, 137). The MC2 receptor is expressed only in the adrenal gland and mediates glucocorticoneogen-esis (123). The MC3 and MC4 receptors are both found in the brain, the MC3 receptor is found in the arcuate nucleus and the nucleus of the solitary tract, whereas the MC4 receptor is mainly found in the hypothalamus (138). Finally, the MC5 receptor is involved in exocrine functions and is localized predominantly in the sebaceous glands (139). The complex role of the melanotropins and the MC receptors, in controlling various physiological functions, has made it difficult to draw simple correlations between these receptors and the... [Pg.60]

The proposed ETV for an MC-receptor pairing (e.g., CL-20-invertebrates) was calculated as the geometric mean of EC20 benchmark toxicity values determined from the individual studies. Following the Eco-SSL derivation methodology [9], at least three toxicity data values generated under specified conditions were required to calculate an ETV. An example of the derivation process for the proposed soil invertebrate-based ETV for CL-20 is shown in Table 12.4. [Pg.289]

Fredriksson R, Lagerstrom MC, Lundin LG et al (2003) The G-protein-coupled receptors in Hie human genome form five main families. Phylogenetic analysis, paralo-gon groups, and fingerprints. Mol Pharmacol 63 1256-1272... [Pg.564]

Michel MC, Beck-Sickinger AG, H Cox et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. Pharmacol Rev 50 143-150... [Pg.831]

Martellotta MC, Cossu G, Fattore L, et al Self-administration of the cannabinoid receptor agonist WIN 55,212—2 in drug-naive mice. Neuroscience 85 327—330, 1998... [Pg.179]

Linert W, Grunert MC, Koudriavtsev AB (2004) Isokenetic and Isoequilibrium Relationships in Spin Crossover Systems. 235 105-136 Liu S, Edwards DS (2002) Fundamentals of Receptor-Based Diagnostic Metalloradio-pharmaceuticals. 222 259-278 Liu Y, see Arico F (2005) 249 in press Liz-Marzan L, see Mulvaney P (2003) 226 225-246 Llamas-Lorente P,see Alajan n M (2005) 250 77-106... [Pg.262]

Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, SchaU TJ (2006) A novel chemokine receptor for SDF-1 and 1-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 203 2201-2213... [Pg.241]

Giimm MC, Ben-Baruch A, Taub DD, Howard OM, Resau JH, Wang JM (1998) Opiates transde-activate chemokine receptors delta and mu opiate receptor-mediated heterologous desensitization. J Exp Med 188(2) 317-325... [Pg.349]

Boadle-Biber, MC (1993) Regulation of serotonin S5mthesis. Prog. Biophys. Molec. Biol. 60 1-15. Curzon, G, Gibson, EL and Oluyomi, AO (1997) Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18 21-25. Gaddum, JH and Picarelli, ZP (1957) Two kinds of tr5 ptamine receptor. Brit. J. Pharmacol. 12 323-328. (Reproduced in Brit. J. Pharmacol. 120 (Suppl) 134-139.)... [Pg.208]

Vila-Coro AJ, Rodriguez-Frade JM, Martin De Ana A, Moreno-Ortiz MC, Martinez AC, Mellado M. The chemokine SDF-lalpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 1999 13(13) 1699-1710. [Pg.285]

Gershengom MC, Geras-Raaka E, Varma A, Clark-Lewis I. Chemokines activate Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest 1998 102(8) 1469-1472. [Pg.330]

Couty JP, Gershengom MC. Insights into the viral G protein-coupled receptor encoded by human herpesvirus type 8 (HHV-8). Biol Cell 2004 96(5) 349-354. [Pg.330]

Arvanitakis L, Geras-Raaka E, Varma A, Gershengom MC, Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 1997 385(6614) 347-350. [Pg.330]

Schuel H, Chang MC, Burkman LJ, Picone R, Makriyannis A, Zimmerman AM, Zimmerman S. Cannabinoid receptors in sperm. Marijuana and Medicine. In Nahas GG et al., eds. Totowa, NJ Humana Press, 1999 317-325. [Pg.134]

Costet, P, Lalanne, F, Gerbod-Giannone, MC, Molina, JR, Fu, X, Lund, EG, Gudas, LJ, and Tall, AR, 2003. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol Cell Biol 23, 7756-7766. [Pg.341]

Ji, Y, Jian, B, Wang, N, Sun, Y, Moya, ML, Phillips, MC, Rothblat, GH, Swaney, JB, and Tall, AR, 1997. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem 272, 20982-20985. [Pg.345]

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MCSS

Proteochemometric Modeling of Chimeric MC Receptors Interacting with MSH Peptides

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