Maytenus ilicifolia

J.H.Y. Vilegas, F.M. Lancas, J.-N. Wauters, L. Angenot, Characterization of adulteration of Espinheira Santa (Maytenus ilicifolia and Maytenus aquifolium, Celastraceae) hydroalcoholic extracts with Sorocea bomplandii (Moraceae) by high-performance thin layer chromatography. Phytochem. Anal. 9 (1998) 263-266. 

Petrovick, P. R. Carlini, E. Antiulcerogenic Preparation from Maytenus ilicifolia and Obtaintion Process. Br. Patent PI 994502, March 6,1999. 

Itokawa H, Shirota O, Ikuta H, Morita H, Takeya K, litaka Y. Triterpenes from rhizomes of Maytenus ilicifolia. Phytochemistry 1991 30 3713-3716. 

Shirota O, Morita H, Takeya K, Itokawa H. Revised structures of cangorosins, triterpene dimers from Maytenus ilicifolia. J. Nat. 107. Prod. 1997 60 111-115. 

Ohsaki A, Imai Y, Naruse M, Ayabe S, Komiyama K, Takashima J. Four new triterpenoids from Maytenus ilicifolia. J. Nat. Prod. 2004 67 469 71. 

An important consideration in the agricultural production of plants containing medicinally active components is that they are sometimes produced by, or in consequence of, microbial agents present in or on the plant. These also constitute part of the biodiversity regulated by law, may be pathogenic to other economic crops and are not always easily cultured. Production in the natural habitat raises no problems. As an example one may notice that the maytansinoids, ansa-macrolides, which form part of the chemical make-up of Maytenus ilicifolia and M. aquifolia, Celastraceae, the two species most highly considered for stomach ulcer treatment, have been shown to be produced by bacteria associated with the plants. ... 

The root extracts of Maytenus senegalensis have been shown to inhibit protein kinase C, as well as having lethality against brine shrimp. The dihydroagarofuran sesquiterpene alkaloids mayteine, putterine A and putterine B have been isolated from the root extracts. Quinonemethide triterpenoids, which have revealed potential anti-tumour and antimicrobial activities, are another diverse group of secondary metabolites from the related species Maytenus ilicifolia. ... 

Bignoniaceae (Tabebuia impetiginosa, heptaphylla, avellanedae, pan d arco) Celasteraceae (Maytenus ilicifolia, espinephra santa)... 

Maytenus ilicifolia Mart, ex Reiss. (Celastraceae) is used as an analgesic, antipyretic, antiseptic and anticancer agent, in South America, and in Paraguay, where it is known as "Cangorosa", it is employed for birth control. Maitenin and pristimerin are this drugs principle, toxic elements. 

Cytotoxic Activity of Triterpenes from Maytenus ilicifolia... 

H. Itokawa, O. Shirota, H. Morita, K. Takeya, N. Tomioka and A. Itai, "New Triterpene Dimers from Maytenus ilicifolia . Tetrahedron Lett., 1990,31, 6881-6882. 

These structures were revised in the literature, "O. Shirota, H. Morita, K. Takeya and H. Itokawa, Revised structures of cangorosins, triterpene dimers from Maytenus ilicifolia, J. Nat. Prod. 60 (2), 111-115 (1997)". The related literatures were as follows, a) Shirota, O., Morita, H., Takeya, K. and Itokawa, H., Structures of Xuxuarines, Stereoisomeric Triterpene Dimers from Maytenus chuchuhuasca. Tetrahedron 51 (4), 1107-1120 (1995), b) Shirota, O., Morita, H., Takeya, K. and Itokawa, H., Novel Stereoisomeric Triterpene Dimers, Xuxuarines Aa and Ap, from Maytenus chuchuhuasca. Chemistry Letters 10I-I02 (1995), c) Shirota, O., Morita, H., Takeya, K. and Itokawa, H., Five New Triterpene Dimers from Mayterms chuchuhuasca, J. Nat. Prod. 60 (11), 1100-1104 (1997) and d) Shirota, O., Morita, H., Takeya, K. and Itokawa, H., New Geometric and Stereoisomeric Triterpene Dimers from Maytenus chuchuhuasca, Chem. Pharm. Bull. 46 (1), 102-106 (1998). 

Maytenus ilicifolia Mart, is a large shrub found in southern Brazil, Paraguay, and Argentina and is claimed to have several medicinal properties. Its reddish to orangish brown bark, known as cangorosa , is... 

Santos VAFFM, Regasini LO, Nogueira CR, Passerini GD, Martinez I, Bolzani VS, et al. Antiprotozal sesquiterpene alkaloids from Maytenus ilicifolia. / Nat Prod... 

Maytenus ilicifolia from southern South America has been used as a menses inducer by indigenous people of Paraguay (Ahmed et al., 1981). 

Ahmed MS, Fong HHS, Soejarto DD, Dobberstein RH et al. 1981 High-performance liquid chromatographic separation and quantitation of maytansinoids in Maytenus ilicifolia. J Chromatogr 213 340-344... 

---