Mannitol production

The mannitol products in this evaluation exhibited large differences in ductility, indicated by their indentation hardness values, as shown in Table 7. Mannogem EZ recorded high hardness, and thus low ductility, relative to the powdered d-(-) mannitol and the granular form, Mannogem 2080, which were considered to be moderately ductile. 

As shown in Table 7, compacts of all three mannitol products displayed relatively low TS at the test SF, particularly the powdered and 2080 grades. Only Mannogem EZ formed tablets with moderate strength. Low TS is perhaps one of the main disadvantages of these mannitol grades, because it contributes relatively little to tablet strength and robustness. 

Mannitol production by homofermentative lactic acid bacteria 392... 

Mannitol production by heterofermrentative lactic acid bacteria 393... 

MANNITOL PRODUCTION BY HOMOFERMENTATIVE LACTIC ACID BACTERIA... 

MANNITOL PRODUCTION BY HETEROFERMENTATIVE LACTIC ACID BACTERIA 393... 

The net gain is 1.25 mol of ATP per mol of fructose fermented. The typical pathway for mannitol production by a heterofermentative LAB from glucose and fructose mixture (1 2) is shown in Figure 21.2. 

Helanto, M., Aarnikunnas, J., von Weymarn, N., Airaksinen, U., Palva, A., and Leisola, M. 2005. Improved mannitol production by a random mutant of Leuconostoc pseudomesenteroides. J. Biotechnol., 116, 283-294. 

Saha, B. C. 2006a. A low-cost medium for mannitol production by Lactobacillus intermedius NRRL B-3693. App. Microbiol. Biotechnol., 72, 676-680. 

Wisselink, H. W., Mars, A. E., van der Meer, P., Eggink, G, and Hugenholtz, J. 2004. Metabolic engineering of mannitol production in Lactococcus lactis influence of overexpression of mannitol-1-phosphate dehydrogenase in different genetic backgrounds. App. Environ. Microbiol., 76,4286 1292. 

G, Hugenholtz, J, et al. 2002. Mannitol production by lactic acid bacteria a review. International Dairy Journal, 12 151-61. 

Ortiz, M.E., Raya, R.R., and Mozzi, E. (2015) Efficient mannitol production by wild-type Lactobacillus reuteri CRL 1101 is attained at constant pH using a simplified culture medium. Appl Microbiol. Biotechnol, 1-13. 

Carvalheiro, F, Moniz, P, Duarte, L.C., Esteves, M.P. et al. (2011) Mannitol production by lactic acid bacteria grown in supplemented carob syrup, /, Ind. Microbid. Biotechnol, 38, 221-227,... 

Eontes, C.P.M.L., Honorato, XL., Rabelo, M.C, and Rodrigues, S. (2009) Kinetic study of mannitol production using cashew apple juice as substrate. Bioprocess. Biosyst. Eng., 32, 493-499. 

Rodriguez, C., Rimaux, X., Fornaguera, M.J, Vrancken, G. et al. (2012) Mannitol production by heterofermentative Lactobacillus reuteri CRL 1101 and Lactobacillus fermentum CRL 573 in free and controlled pH batch fermentations, Appl Microbiol Biotechnol, 93, 2519-2527. 

Wisselink, H. W., Weusthuis, R. A., Eggink, G., Hugenholtz, J., Grobben, G. J. (2002). Mannitol production by lactic acid bacteria a review. International Dairy Journal, 12(2—3), 151-161. 

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