Mallinckrodt Laboratory Chemicals

Mallinckrodt Laboratory Chemicals Mitsubishi Chemicals (Japan)... 

Premixed blends of acrylamide and bisacrylamide prepared with varius ratios of monomers were purchased from Eastman Kodak Chemical Company (Rochester, NY). The 37.5 1 and the 19 1 preparations were used for the study. Gels made from these mixtures will be referred to as 2.6% and 5% cross-linked polyacrylamides, respectively. Five grams of each monomer blend were added to 95-g portions of distilled water. Solution was achieved by mixing for 1 h. To each sample was added 1 ml each of a 1% solution of N, N, N, N -tetramethylethylenediamine (Eastman Chemical Co., New Haven, CT) and a 10% solution of ammonium persulfate (Mallinckrodt Laboratory Chemicals, Phillipsburg, N.1). The solutions were poured into an open polyethylene mold and allowed to cure for 12 h at room temperature. The gels were carefully removed and placed in an excess of distilled sterile water for 48 h. The water was replaced several times during the equilibration period. It was felt that this was sufficient to remove unreacted monomers and impurities. The gels were then cut with a steel-ruled die into circles 40 imn in diameter. 

Mallinckrodt Baker Laboratory Chemicals Medical Chemical Corp. 

Laboratories participating in these studies include Allied-Signal Engineered Materials Research Center, Phillips Petroleum, Akzo Chemie, Shell, Monsanto, Mallinckrodt, Haldor Topsoe, Nalco Chemical, American Cyanamid, Union Carbide, and Exxon Chemical. 

Mallinckrodt Chemical Laboratory, Harvard University, Cambridge, Massachusetts... 

Materials. Standards of morphine, 6-acetylmorphine, 6-acetyl-codeine, heroin and morphine N-oxide were supplied by the Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, Virginia. Acetic anhydride (Analytical Reagent) was by Mallinckrodt Chemical Works, St. Louis, Missouri (Lot ZGB-B). 

Available from MaDinckrodt Chemical Works, Second and Mallinckrodt Streets, St. Louis, Missouri, 63160 and Burdick Jackson Laboratories, Muskegon, Midiigan, 49442. 

Cocaine 1 hydrochloride (Mallinckrodt Chemical Works) was converted to the free base in the electrochemical cell by addition of NaOH (0 125 M), Norcocaine 2 (used as oil) was prepared by the method of Lazer et al. hydrochloride, mp 114-115 C, lit. mp 115-117 C m/z(EI) 289 (2-HCl). Norcocaine nitroxide 3 was obtained as an oil from 2 using m-chloroperbenzoic acid m/z(EI) 304(3) the sample also contained some m-chlorobenzoic acid. Di- and tri-n-butylamines (Eastman and K and K Laboratories) were distilled from caustic pellets. For electrochemical analysis the solvents acetonitrile (Chempure or Aldrich) and dimethyl-formamide (DMF) (Aldrich) were used without further purification. The electrolyte was tetraethylammonium perchlorate (TEAP) (G.F. Smith Chemical Co.). 

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