Malignant tumors human colorectal tumor

Colorectal adenocarcinoma is one of the most common malignancies in humans and a major cause of cancer related mortality. Colorectal adenocarcinoma develops from intestinal mucosal cells after a cascade of genetic alterations. The most important prognostic parameter for all types of carcinoma is the TNM status including tumor... 

Most malignant solid tumors contain elevated levels of hyaluronan [17, 59). High levels of hyaluronan expression correlate with poor differentiation in human ductal breast carcinomas [60] and with poor survival rates in human colorectal adenocarcinomas [61]. Enrichment of hyaluronan in tumors can be due to increased production by tumor cells themselves or to interactions between tumor cells and surrounding stromal cells that induce increased production by the latter. In accordance with the latter, hyaluronan accumulation occurs at the interface of tumor invasion into host tissues in various tumor types [17, 57, 59, 62]. 

IL-2 has been approved for the heatment of renal cell carcinoma and also has shown good activity in malignant melanoma. Both of these tumors are refractory to chemotherapy. IL-2 has also been used invesdgationally, both alone and in combinadon with LAK cells, with chemotherapy and with other biological response modifier s (BRM s) to d eat a variety of different cancers (e.g., head and neck carcinoma, colorectal cancer, cend al nervous system cancer etc). In addidon to cancer therapy, IL-2 has been used to d eat padents infected with human immunodeficiency virus and it has been used ex vivo to generate antiviral T cells which were reinfused into padents (Lewko and Oldham, 2003 Dorr, 1993). 

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