Malignant arrhythmias

Kozak, M., Izakovicova, H. L., Krivan, L., et al. (2004) Endothelin-1 gene polymorphism in patients with malignant arrhythmias. J. Cardiovasc. Pharmacol. 44, S92-S95. 

Bagattin, A., Veronese, C., Bauce, B., Wuyts, W., Settimo, L., Nava, A., Rampazzo, A., and Danieli, G. A. (2004). Denaturing HPLC-Based Approach for Detecting RYR2 Mutations Involved in Malignant Arrhythmias. Clin Chem 50(7) 1148—55. 

Increased risk of ischemia, reinfarction, and malignant arrhythmias ETT may clarify risk... 

Rarely malignant arrhythmias during sexual activity may cause sudden death Risk is decreased by an implanted defibrillator or pacemaker Obstructive hypertrophic cardiomyopathies... 

Agarwal B, Agarwal R, and Misra D (1977) Malignant arrhythmias induced by accidental aconite poisoning. 

Clearly, coronary microembolization is a frequent event in ischemic heart disease, spontaneously in patients with unstable angina / acute coronary syndromes as well as artificially during coronary interventions with typical consequences, such as malignant arrhythmias and contractile dysfunction (Figure 7). The resulting microcirculatory impairment causes patchy microinfarction, and is often associated with coronary hyperemia at baseline and, conversely, transiently reduced coronary reserve. These obser-... 

Endothelin-1 gene polymorphism in patients with malignant arrhythmias. J Cardiovasc Pharmacol 44 S92-S95... 

Billman, G.E., 1993. The effect of adrenergic receptor antagonists on cocaine-induced ventricular fibrillation alpha but not beta adrenergic receptor antagonists prevent malignant arrhythmias independent of heart rate. J. Pharmacol. Exp. Ther. 269, 409-416. 

Death attributable to malignant arrhythmias has been reported after days to weeks of cancer chemotherapy regimens administering 0.15 mg/kg/day of arsenic trioxide intravenously. 

Agarwal, B.L., R.K. Agarwal, and D.N. Misra. 1977. Malignant arrhythmias induced by accidental aconite poisoning. Indian Heart J. 29(5) 246-248. 

Andreoli TE Ion transport disorders introductory comments. Am J Med 1998 104 85. (First of a series of articles on ion transport disorders published between January and August, 1998. Topics covered were structure and function of ion channels, arrhythmias and antiarrhythmic drugs, Liddle syndrome, cholera, malignant hyperthermia, cystic fibrosis, the periodic paralyses and Bartter syndrome, and Gittelman syndrome.)... 

Hypercalcemia of malignancy develops quickly and is associated with anorexia, nausea and vomiting, constipation, polyuria, polydipsia, and nocturia. Hypercalcemic crisis is characterized by acute elevation of serum calcium to greater than 15 mg/dL, acute renal failure, and obtundation. Untreated hypercalcemic crisis can progress to oliguric renal failure, coma, and life-threatening ventricular arrhythmias. 

Garberoglio, L., Giustetto, C., Wolpert, C. and Gaita, F. (2007) Is acquired short QT due to digitalis intoxication responsible for malignant ventricular arrhythmias Journal of Electrocardiology, 40, 43—46. 

Succinylcholine-induced hyperkalemia may lead to cardiac arrhythmia and arrest when plasma reaches 7 and 10 mM, respectively. The drug also may precipitate a fulminant attack of malignant hyperthermia in susceptible individuals (not to be confused with neuroleptic malignant hyperpyrexia, which involves dopamine and the CNS). Treatment in either case consists of cooling the body and administering oxygen and dantrolene sodium (discussed later). 

Rare reactions include seizures and neuroleptic malignant syndrome, a potentially fatal syndrome characterized by hyperpyrexia, muscle rigidity, irregular pulse or BP, tachycardia, diaphoresis, and cardiac arrhythmias. 

As conduction times are prolonged, the chance of developing reentry arrhythmias grows. Malignant ventricular arrhythmias are uncommon in mild or moderate overdoses, but they are more likely in severe cases. 

Administration of arsenite in cancer chemotherapy regimens, often at a daily dose of 10-20 mg for weeks to a few months, has been associated with prolongation of the QT interval on the electrocardiogram and occasionally has resulted in malignant ventricular arrhythmias such as torsade de pointes. 

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