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Beta-adrenergic receptor antagonists

Clinical Trials. In Phase I studies, good documentation and additional investigations should be standard practice. Serious reactions are pretty unusual in these studies, which will detect only very common ADRs, in particular those that are pharmacologically mediated (e.g., bradycardia with beta adrenergic receptor antagonists). [Pg.846]

Beta adrenergic receptor antagonists reduce cardiac output (caused by negative chronotropic and inotropic effects), decrease renin release from the kidneys, and cause smooth muscle relaxation. However, blockage may also decrease secretion of insulin from pancreatic P-cells, which limits its use in T2D. Calcium channel antagonists act on L-type voltage gated channels in the heart and blood vessels to reduce vascular resistance and arterial pressure. Diuretics are also widely used to decrease blood pressure, particularly in the elderly and hypertensive black populations. [Pg.1025]

Patil, P. N. Steric aspects of adrenergic drugs.8. Optical isomers of beta adrenergic receptor antagonists. J. Pharmacol. Exp. Ter. 1968, 160, 308-314. [Pg.547]

Billman, G.E., 1993. The effect of adrenergic receptor antagonists on cocaine-induced ventricular fibrillation alpha but not beta adrenergic receptor antagonists prevent malignant arrhythmias independent of heart rate. J. Pharmacol. Exp. Ther. 269, 409-416. [Pg.99]

Celiprolol is a potent beta -adrenergic receptor antagonist. It has intrinsic sympathomimetic action, possesses some alpha2-adrenoreceptor antagonistic properties, is a direct vasodilator, and a direct bronchodilator. Celiprolol is incompletely and variably absorbed, eliminated both in bile and urine, and has a half-life of 4 to 5 hours. Celiprolol (200 to 400 mg/day) has efficacy similar to atenolol or propranolol in reducing blood pressure and is useful in hypertensive patients with asthma or bronchitis. Furthermore, celiprolol is as effective as atenolol in treating patients with stable angina. [Pg.141]

Therapeutic Function Beta-adrenergic receptor antagonist... [Pg.256]

Murmann, W., Rumore, G. and Gamba, A. (1967) Pharmacological properties of l-(4 -nitrophenyl)-2-isopropylamino-ethanol (INPEA), a new beta-adrenergic receptor antagonist. V. Effects of the optical isomers D(minus) and L(plus) INPEA on heart rate, oxygen consumption and body temperature and on the cardiac and metabolic effects of adrenaline and noradrenaline in urethane-anesthetized rats. Boll. Chim. Farm., 106, 251-268. [Pg.225]


See other pages where Beta-adrenergic receptor antagonists is mentioned: [Pg.359]    [Pg.211]    [Pg.198]    [Pg.359]    [Pg.14]    [Pg.208]    [Pg.248]    [Pg.194]    [Pg.531]    [Pg.10]    [Pg.244]    [Pg.509]    [Pg.509]   
See also in sourсe #XX -- [ Pg.211 ]

See also in sourсe #XX -- [ Pg.550 ]

See also in sourсe #XX -- [ Pg.550 ]




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Adrenergic antagonists

Adrenergic receptor antagonists

Adrenergic receptors receptor

Beta Antagonists

Beta receptors

Beta-adrenergic-receptor agonists/antagonists

Beta-receptor antagonists

Receptor beta adrenergic

Receptors 3-adrenergic

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