Major histocompatibility complex haplotypes

The pathogenesis of type I diabetes is autoimmune destruction of the cells of the pancreas. The factor or factors that trigger this autoimmune response are unknown. Predisposing factors appear to include certain major histocompatibility complex haplotypes and autoantibodies to various islet cell antigens. The progression of the autoimmune response is characterized by lymphocytic infiltration and destruction of the pancreatic cells resulting in insulin deficiency. Type I diabetes mellitus constitutes about 10% of cases of diabetes mellitus. 

Dawkins R, Leelayuwat C, Gaudieri S, Tay G, Hui J, Cattley S, Martinez P, Kulski J. Genomics of the major histocompatibility complex Haplotypes, duplication, retroviruses and disease. Immunol Rev 1999 167 275-304. 

Chen, Y.-G., Silveira, P., Osborne, M. A., Chapman, H. D. and Serreze, D. V. (2007) Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes 56, 424M 30. 

Fraser PA, Yunis EJ, Alper CA Excess admixture proportion of extended major histocompatibility complex haplotypes of Caucasian origin among rheumatoid arthritis associated haplotypes in African Americans and Afro-Caribbeans. Ethnicity and Health 1(2) 153-159,1996 Fuhr U Drug interactions with grapefruit juice extent, probable mechanism and clinical relevance. Drug Saf 18 251-272,1998 Garrity JA, Gay PE (eds) The Columbia History of the World. New York, Harper Row, 1972... 

Aten, J. et al., Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur. J. Immunol., 21, 611, 1991. 

Haplotypes The genetic constitution of individuals with respect to one member of a pair of aUehc genes, or sets of genes that are closely linked and tend to be inherited together such as those of the major histocompatibility complex. [NIH]... 

Briles, W.E. Briles, R.W. (1982). Identification of haplotypes of the chicken major histocompatibility complex. Immunogenetics, 15, 449-59. 

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